Russian Journal of General Chemistry

, Volume 87, Issue 12, pp 2937–2943 | Cite as

Synthesis, Characterization, and Anticancer Activity of Organotin(IV) Complexes with Sodium 3-(1H-Indol-3-yl)propanoate

Letters to the Editor


Six organotin(IV) complexes have been synthesized by refluxing sodium salt of 3-(1H-indol-3-yl)-propanoic acid with di- and triorganotin chlorides in 1: 1 and 2: 1 molar ratios, respectively. These complexes have been characterized by elemental analysis, IR, and 1H, 13C, and 119Sn NMR spectral data. DNA binding studies were performed by viscometric measurements and UV-Vis spectroscopy. Both techniques indicated an intercalation mode of interaction. Cytotoxic activity of the ligand salt and organotin(IV) complexes 1–6 was tested against human ovarian cell line A2780. Results of bioassay revealed that organotin derivatives were more active than anticancer drug cis-platin. Triorganotin(IV) compounds had higher cytotoxic activity than corresponding diorganotin(IV) complexes.


organotin(IV) complexes IR NMR DNA interaction cytotoxicity human ovarian cell line A2780 


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Copyright information

© Pleiades Publishing, Ltd. 2017

Authors and Affiliations

  1. 1.Department of ChemistryQuaid-i-Azam UniversityIslamabadPakistan
  2. 2.Department of ChemistryUniversity of Sargodha, Lyallpur CampusFaisalabadPakistan

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