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Russian Journal of General Chemistry

, Volume 87, Issue 12, pp 2909–2914 | Cite as

Antimicrobial Activity of Some New N-Glycosylidene Carbohydrazide Derivatives

Letters to the Editor
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Abstract

New N-glycosyl carbohydrazide derivatives and their annulated C-nucleosides have been synthesized via reaction of N-[4-(hydrazinecarbonyl)phenyl]-8-hydroxy-7-iodoquinoline-5-sulfonamide with different aldoses and characterized by spectroscopic and elemental analyses. Some selected compounds have been screened for activity and 4d showed maximum antimicrobial activity comparable to that of standard drugs.

Keywords

8-hydroxy-7-iodoquinolin-5-sulfonamide derivatives nucleoside analogs antimicrobial agents 

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Copyright information

© Pleiades Publishing, Ltd. 2017

Authors and Affiliations

  • N. M. Khalifa
    • 1
    • 2
  • M. A. Al-Omar
    • 1
  • E. S. Nossier
    • 3
  1. 1.Department of Pharmaceutical Chemistry, Drug Exploration and Development Chair (DEDC), College of PharmacyKing Saud UniversityRiyadhSaudi Arabia
  2. 2.Department of Therapeutical Chemistry, Pharmaceutical and Drug Industries DivisionNational Research CentreDokki, CairoEgypt
  3. 3.Department of Pharmaceutical Chemistry, Faculty of Pharmacy (Girls)Al-Azhar UniversityCairoEgypt

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