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Russian Journal of General Chemistry

, Volume 87, Issue 12, pp 2898–2901 | Cite as

Cyclic Amidoalkylation of Hydrophosphorylic Compounds. Synthesis of Proline Analogs

  • A. V. Vinyukov
  • M. E. Dmitriev
  • A. N. Yarkevich
  • V. V. Ragulin
Letters to the Editor
  • 20 Downloads

Abstract

A method for the synthesis of N-Cbz-protected phosphorylic analogs of proline by cyclic amidoalkylation of various hydrophosphorylic compounds was developed. Combination of amide and carbonyl fragments in the 4-N-Cbz-aminobutyraldehyde molecule allows to realize the three-center two-component amide version of the Kabachnik–Fields reaction.

Keywords

phosphorylic analogs of proline cyclic amidoalkylation 4-aminobutyraldehyde 

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Copyright information

© Pleiades Publishing, Ltd. 2017

Authors and Affiliations

  • A. V. Vinyukov
    • 1
  • M. E. Dmitriev
    • 1
  • A. N. Yarkevich
    • 1
  • V. V. Ragulin
    • 1
  1. 1.Institute of Physiologically Active SubstancesRussian Academy of SciencesChernogolovka, Moscow oblastRussia

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