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Russian Journal of General Chemistry

, Volume 87, Issue 12, pp 2794–2800 | Cite as

Modification of Diphenylphosphorylacetic Hydrazide with Thiosemicarbazide and Triazole Units

  • I. A. Krutov
  • E. L. Gavrilova
  • R. N. Burangulova
  • S. S. Kornilov
  • A. A. Valieva
  • A. I. Samigullina
  • A. T. Gubaidullin
  • O. G. Sinyashin
  • I. I. Semina
  • D. O. Nikitin
  • A. V. Plotnikova
Article

Abstract

Thiosemicarbazides of diphenylphosphorylacetic acid and their cyclic derivatives have been synthesized. Functionalization of the obtained 1,2,4-triazole-3-thiones with ethyl 2-bromoacetate at the sulfur atom has been carried out, the obtained esters have been transformed into the corresponding hydrazides via hydrazinolysis. Preliminary pharmacological tests of the synthesized compounds have been performed.

Keywords

phosenazide 1,2,4-triazole-3-thione thiosemicarbazide hydrazides 

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Copyright information

© Pleiades Publishing, Ltd. 2017

Authors and Affiliations

  • I. A. Krutov
    • 1
  • E. L. Gavrilova
    • 1
  • R. N. Burangulova
    • 1
  • S. S. Kornilov
    • 1
  • A. A. Valieva
    • 1
  • A. I. Samigullina
    • 2
  • A. T. Gubaidullin
    • 2
  • O. G. Sinyashin
    • 1
    • 2
  • I. I. Semina
    • 3
  • D. O. Nikitin
    • 3
  • A. V. Plotnikova
    • 3
  1. 1.Kazan National Research Technological UniversityKazan, TatarstanRussia
  2. 2.A.E. Arbuzov Institute of Organic and Physical Chemistry, Kazan Scientific CenterRussian Academy of SciencesKazan, TatarstanRussia
  3. 3.Kazan State Medical UniversityKazan, TatarstanRussia

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