Russian Journal of General Chemistry

, Volume 87, Issue 12, pp 2776–2782 | Cite as

Synthesis and Biological Activity of 3,4-Diaryl-5-[4-(acetylsulfamoyl)phenyl]-4,5-dihydropyrrolo[3,4-c]pyrazol-6(2H)-ones and Their Sodium Salts

  • O. V. Bobrovskaya
  • V. L. Gein
  • G. V. Seliverstov
  • S. V. Chashchina
  • M. V. Dmitriev
Article
  • 6 Downloads

Abstract

3,4-Diaryl-5-[4-(acetylsulfamoyl)phenyl]-4,5-dihydropyrrolo[3,4-c]pyrazol-6(2H)-ones were synthesized be reaction of 5-aryl-4-aroyl-1-[4-(acetylsulfamoyl)phenyl]-3-hydroxy-1H-pyrrole-2(5H)-ones with hydrazine hydrate in glacial acetic acid, and their sodium salts were obtained by treatment with sodium methoxide in methanol–DMF (1: 1). Analgesic and anti-inflammatory activity and acute toxicity of the synthesized compounds were studied.

Keywords

pyrrolo[3,4-c]pyrazol-6-ones pyrrolo[3,4-c]pyrazol-6-one sodium salts analgesic activity anti-inflammatory activity acute toxicity 

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Copyright information

© Pleiades Publishing, Ltd. 2017

Authors and Affiliations

  • O. V. Bobrovskaya
    • 1
  • V. L. Gein
    • 1
  • G. V. Seliverstov
    • 1
  • S. V. Chashchina
    • 1
  • M. V. Dmitriev
    • 2
  1. 1.Perm State Pharmaceutical AcademyPermRussia
  2. 2.Perm State National Research UniversityPermRussia

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