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Russian Journal of General Chemistry

, Volume 87, Issue 1, pp 154–155 | Cite as

Synthesis of 9-aryl-3,4,6,7,9,10-hexahydroacridine-1,8(2Н,5Н)-diones

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Abstract

The reaction in a mixture of 1,3-cyclohexanedione (dimedone), arylaldehyde, and ammonium acetate at 160°C during 10–15 min in the absence of solvent leads to the formation of 9-aryl-3,4,6,7,9,10-hexahydroacridine-1,8(2H,5H)-diones. The structure of the products has been confirmed by IR and 1H NMR spectroscopy data. Antimicrobial activity of the obtained compounds has been studied.

Keywords

9-aryl-3,4,6,7,9,10-hexahydroacridine-1,8(2Н,5Н)-dione Hantzsch synthesis antimicrobial activity 

References

  1. 1.
    Mashkovskii, M.D., Lekarstvennye sredstva (Drugs), Moscow RIA Novaya Volna, 2005.Google Scholar
  2. 2.
    Chebanov, V.A., Saraev, V.E., and Kobzar, K.M., Chem. Heterocycl. Compd., 2004, vol. 40, no. 4, p. 475. doi 10.1023/B:COHC.0000033541.49115.a0CrossRefGoogle Scholar
  3. 3.
    Wang, G.W. and Miao, C.B., Green Chem., 2006, no. 8, p. 1080. doi 10.1039/B604064KCrossRefGoogle Scholar
  4. 4.
    Rukovodstvo po eksperimental’nomu (doklinicheskomu) izucheniyu novykh farmakologicheskikh veshchestv [Manual on Experimental (Preclinical) Study of New Pharmacological Substances], Khabriev, R.U., Ed., Moscow Meditsina, 2005.Google Scholar

Copyright information

© Pleiades Publishing, Ltd. 2017

Authors and Affiliations

  • O. E. Nasakin
    • 1
  • M. I. Kazantseva
    • 1
  • V. L. Gein
    • 2
  1. 1.Chuvash State UniversityCheboksaryRussia
  2. 2.Perm State Pharmaceutical AcademyPermRussia

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