Little artifices of huge libraries: Secrets of parallel liquid-phase synthesis

Abstract

Key aspects of differences between liquid-phase parallel synthesis and preparation of a single compound at a time are reviewed. Specific technique and equipment is required to make in the parallel manner such processes as heating (involving MW ovens and flow microreactors), extraction, filtration, and chromatography. Rich illustrations may be useful in educational courses on medicinal and combinatorial chemistry.

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Correspondence to E. V. Babaev.

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Original Russian Text © E. V. Babaev, 2009, published in Rossiiskii Khimicheskii Zhurnal, 2009, Vol. 53, No. 5, pp. 96–104.

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Babaev, E.V. Little artifices of huge libraries: Secrets of parallel liquid-phase synthesis. Russ J Gen Chem 80, 2607–2616 (2010). https://doi.org/10.1134/S1070363210120273

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Keywords

  • General Chemistry
  • Reaction Vessel
  • Flash Chromatography
  • Combinatorial Chemistry
  • Parallel Filtration