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Crystal Structure and Anti-kidney Cancer Activity of Two Novel Coordination Polymers {[Cu2(DCTP)2](H2O)}n and {[Zn5(NTB)4(DMF)2](NH2NMe2)(DMF)3}n

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Abstract

Two new coordination polymers, namely {[Cu2(DCTP)2](H2O)}n (I) (H2DCTP = 4'-(3,5-dicarboxyphenyl)-4,2':6',4''-terpyridine) and {[Zn5(NTB)4(DMF)2](H2NMe2)2(DMF)3}n (II) (H3NTB = 4,4′,4″-nitrilotribenzoic acid, DMF = N,N-dimethylformamide), have been successfully constructed under solvothermal conditions. The structures of two complexes have been successfully determined by single crystal X-ray diffraction (CIF files CCDC nos. 1852377 (I) and 1852378 (II)). In addition, in vitro antitumor activity of compounds I and II on four human kidney cancer cells (GRC-1, A-498, ACHN and 786-P) was further determined and the results show that the two compounds showed promising activity.

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ACKNOWLEDGMENTS

This research was supported by Zhejiang Provincial Natural Science Foundation of China (no. LY14H050006).

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Authors and Affiliations

  1. Department of Nephrology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, P.R. China

    F. Lin, X. Q. Chen, Q. X. Zhou, Y. Zhou & B. C. Chen

  2. Department of Nephrology, Shenzhen University General Hospital, Shenzhen, Guangdong, P.R. China

    F. Lin

  3. Department of Cardiology, Shenzhen University General Hospital, Shenzhen, Guangdong, P.R. China

    F. Q. Dong

  4. Shenzhen University Clinical Medical Academy, Shenzhen, Guangdong, P.R. China

    F. Q. Dong

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  1. F. Lin
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  2. F. Q. Dong
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  3. X. Q. Chen
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  4. Q. X. Zhou
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  5. Y. Zhou
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  6. B. C. Chen
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Correspondence to F. Lin.

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Lin, F., Dong, F.Q., Chen, X.Q. et al. Crystal Structure and Anti-kidney Cancer Activity of Two Novel Coordination Polymers {[Cu2(DCTP)2](H2O)}n and {[Zn5(NTB)4(DMF)2](NH2NMe2)(DMF)3}n. Russ J Coord Chem 44, 824–830 (2018). https://doi.org/10.1134/S1070328419010044

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