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Coordination Compounds of Cobalt(II), Nickel(II), and Copper(II) Halides with 2-Methyl-1,2,4-Triazolo[1,5-a]benzimidazole

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Abstract

New coordination compounds of Co(II), Ni(II), and Cu(II) halides with 2-methyl-1,2,4-triazolo[1,5-a]benzimidazole (L), [Co(L)2Cl2] (Ia), [Ni(L)2(H2O)4]Cl2 · 4H2O (II), and [Сu2(L)4(µ-Br)2Br2] (IIIa), are synthesized. The complexes are studied by X-ray structure analysis (СIF files CCDC nos. 1825006–1825008), electronic (diffuse reflectance) spectroscopy, and IR spectroscopy. In compounds Ia, II, and IIIa, ligand L is coordinated to the metal by the N4 atom of the triazole fragment. The study of the cytotoxic effect of the ligand and synthesized complexes on the Hep-2 line (laryngeal cancer cells) shows a considerably higher activity of the copper(II) complex than that of the ligand.

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ACKNOWLEDGMENTS

The cytotoxicity of the synthesized compounds was studied using the equipment of the Proteomics Center for Collective Use at the Institute of Molecular Biology and Biophysics of the Federal Research Center of Fundamental and Translational Medicine (Novosibirsk, Russia).

The authors are grateful to N.P. Korotkevich for the detection of diffraction patterns, to N.I. Alferova for recording IR spectra, and to I.V. Yushina for recording electronic spectra.

This work was supported by the Russian Foundation for Basic Research, project no. 16-53-00020 Vel_a.

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Authors and Affiliations

  1. Nikolaev Institute of Inorganic Chemistry, Siberian Branch, Russian Academy of Sciences, 630090, Novosibirsk, Russia

    I. I. Dyukova, V. Yu. Komarov, T. S. Sukhikh & L. G. Lavrenova

  2. Novosibirsk National State Research University, 630090, Novosibirsk, Russia

    I. I. Dyukova, V. Yu. Komarov, T. S. Sukhikh & L. G. Lavrenova

  3. Institute of Physical and Organic Chemistry, Southern Federal University, Rostov-on-Don, Russia

    T. A. Kuz’menko

  4. Institute of Molecular Biology and Biophysics, Federal Research Center of Fundamental and Translational Medicine, Novosibirsk, Russia

    E. V. Vorontsova

Authors
  1. I. I. Dyukova
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  2. T. A. Kuz’menko
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  3. V. Yu. Komarov
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  4. T. S. Sukhikh
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  5. E. V. Vorontsova
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  6. L. G. Lavrenova
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Correspondence to I. I. Dyukova or L. G. Lavrenova.

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Translated by E. Yablonskaya

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Dyukova, I.I., Kuz’menko, T.A., Komarov, V.Y. et al. Coordination Compounds of Cobalt(II), Nickel(II), and Copper(II) Halides with 2-Methyl-1,2,4-Triazolo[1,5-a]benzimidazole. Russ J Coord Chem 44, 755–764 (2018). https://doi.org/10.1134/S107032841812014X

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  • DOI: https://doi.org/10.1134/S107032841812014X

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