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Crystal Structure and Biological Activity of Two Novel Coordination Polymers as Anti-Gastric Cancer Agents

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Abstract

Two new coordination polymers, namely [Cd2(Mna)2(Phen)]n (I) (H2Mna = 6-mercaptonicotinic acid, Phen = 1,10-phenanthroline) and {[Mn(Ddca)(Phen)](H2O)}n (II) (H2Ddca = 6,6'-dithiodinicotinic acid), have been obtained by using H2Ddca and Phen as the organic building blocks under different reaction conditions. The structures of these complexes have been successfully determined by single crystal X-ray diffraction (CIF files CCDC nos. 1811835 (I), 1811836 (II)). In addition, in vitro antitumor activity of compounds I and II on four human gastric cancer cells (MGC-803, BGC-823, SGC-7901 and AGS) was further determined and the results show that the two compounds showed promising activity.

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Authors and Affiliations

  1. Department of General Surgery, Ruian People’s Hospital, Wenzhou, Zhejiang, P.R. China

    Q. L. Zhou, Z. Z. Zeng & H. C. Chen

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  1. Q. L. Zhou
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  2. Z. Z. Zeng
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  3. H. C. Chen
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Correspondence to H. C. Chen.

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Zhou, Q.L., Zeng, Z.Z. & Chen, H.C. Crystal Structure and Biological Activity of Two Novel Coordination Polymers as Anti-Gastric Cancer Agents. Russ J Coord Chem 44, 579–583 (2018). https://doi.org/10.1134/S1070328418090087

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  • DOI: https://doi.org/10.1134/S1070328418090087

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