Russian Journal of Bioorganic Chemistry

, Volume 44, Issue 2, pp 229–237 | Cite as

Synthesis, Fungistatic, Protistocidal, and Antibacterial Activity of 1-(3-Amino-2-Hydroxypropyl)Indoles

  • K. F. Suzdalev
  • L. D. Popov
  • A. A. Zubenko
  • Yu. D. Drobin
  • L. N. Fetisov
  • A. N. Bodryakov
  • N. M. Serbinovskaya
Article

Abstract

A series of new indole derivatives containing the 3-amino-2-hydroxypropyl group at the nitrogen atom has been synthesized by the ring-opening of the oxirane cycle of 1-oxiranylmethylindoles. Their antibacterial, fungicidal, and protistocidal activities have been studied. Most of the synthesized compounds have been shown to exhibit a high protistocidal activity that several times exceeds that of the reference drug, baikoks (toltrazuril).

Keywords

indole oxiranes chalcones 1,2-amino alcohols antibacterial fungistatic protistocidal activity 

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Copyright information

© Pleiades Publishing, Ltd. 2018

Authors and Affiliations

  • K. F. Suzdalev
    • 1
  • L. D. Popov
    • 1
  • A. A. Zubenko
    • 2
  • Yu. D. Drobin
    • 2
  • L. N. Fetisov
    • 2
  • A. N. Bodryakov
    • 1
  • N. M. Serbinovskaya
    • 2
  1. 1.Chemical Department of Southern Federal UniversityRostov-on-DonRussia
  2. 2.North-Caucasian Zonal Scientific Research Veterinary InstituteNovocherkasskRussia

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