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Synthesis, Fungistatic, Protistocidal, and Antibacterial Activity of 1-(3-Amino-2-Hydroxypropyl)Indoles

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Abstract

A series of new indole derivatives containing the 3-amino-2-hydroxypropyl group at the nitrogen atom has been synthesized by the ring-opening of the oxirane cycle of 1-oxiranylmethylindoles. Their antibacterial, fungicidal, and protistocidal activities have been studied. Most of the synthesized compounds have been shown to exhibit a high protistocidal activity that several times exceeds that of the reference drug, baikoks (toltrazuril).

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Authors and Affiliations

  1. Chemical Department of Southern Federal University, Rostov-on-Don, 344090, Russia

    K. F. Suzdalev, L. D. Popov & A. N. Bodryakov

  2. North-Caucasian Zonal Scientific Research Veterinary Institute, Novocherkassk, 346421, Russia

    A. A. Zubenko, Yu. D. Drobin, L. N. Fetisov & N. M. Serbinovskaya

Authors
  1. K. F. Suzdalev
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  2. L. D. Popov
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  3. A. A. Zubenko
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  4. Yu. D. Drobin
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  5. L. N. Fetisov
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  6. A. N. Bodryakov
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  7. N. M. Serbinovskaya
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Corresponding author

Correspondence to K. F. Suzdalev.

Additional information

Original Russian Text © K.F. Suzdalev, L.D. Popov, A.A. Zubenko, Yu.D. Drobin, L.N. Fetisov, A.N. Bodryakov, N.M. Serbinovskaya, 2018, published in Bioorganicheskaya Khimiya, 2018, Vol. 44, No. 2, pp. 217–224.

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Suzdalev, K.F., Popov, L.D., Zubenko, A.A. et al. Synthesis, Fungistatic, Protistocidal, and Antibacterial Activity of 1-(3-Amino-2-Hydroxypropyl)Indoles. Russ J Bioorg Chem 44, 229–237 (2018). https://doi.org/10.1134/S106816201801017X

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  • DOI: https://doi.org/10.1134/S106816201801017X

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