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The Synthesis of (1,3,4-Oxadiazol-2-yl)Acrylic Acid Derivatives with Antibacterial and Protistocidal Activities

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Abstract

A series of new 1,3,4-oxadiazol-2-yl-acrylic acids was synthesized by cyclization of 4-(2-R-hydrazino)- 4-oxo-2-butenic acids, and their antibacterial and protistocidal activities were studied. The p-substituted benzyl derivatives in the Z-form were shown to exhibit a high protistocidal activity, which exceeded that of the reference drug Baycox (toltrazuril) by several times, whereas the 3-hydroxy-2-naphthyl derivative, in addition to a very high protistocidal activity, also exhibited a moderate antibacterial activity.

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Authors and Affiliations

  1. Department of Chemistry, Southern Federal University, Rostov-on-Don, 344090, Russia

    L. D. Popov & S. A. Borodkin

  2. North-Caucasian Zonal Scientific Research Veterinary Institute, Novocherkassk, 346421, Russia

    A. A. Zubenko, L. N. Fetisov, Yu. D. Drobin & A. N. Bodryakov

  3. Don State Agrarian University, Persianovskii, 346493, Russia

    A. I. Klimenko

  4. Rostov-on-Don Basic Medical College, Rostov-on-Don, 344022, Russia

    I. E. Melkozerova

Authors
  1. L. D. Popov
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  2. A. A. Zubenko
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  3. L. N. Fetisov
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  4. Yu. D. Drobin
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  5. A. I. Klimenko
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  6. A. N. Bodryakov
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  7. S. A. Borodkin
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  8. I. E. Melkozerova
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Corresponding author

Correspondence to L. D. Popov.

Additional information

Original Russian Text © L.D. Popov, A.A. Zubenko, L.N. Fetisov, Yu.D. Drobin, A.I. Klimenko, A.N. Bodryakov, S.A. Borodkin, I.E. Melkozerova, 2018, published in Bioorganicheskaya Khimiya, 2018, Vol. 44, No. 2, pp. 225–231.

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Popov, L.D., Zubenko, A.A., Fetisov, L.N. et al. The Synthesis of (1,3,4-Oxadiazol-2-yl)Acrylic Acid Derivatives with Antibacterial and Protistocidal Activities. Russ J Bioorg Chem 44, 238–243 (2018). https://doi.org/10.1134/S1068162018010132

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  • DOI: https://doi.org/10.1134/S1068162018010132

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