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A Role of Vesicular Transduction of Intercellular Signals in Cancer Development

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Abstract

Export of biologically active compounds is essential for any living cell. Transport of bioactive molecules through a cellular membrane can be active, or passive, or vesicular. In the past decade, vesicular transduction of intercellular signals has attracted great interest in the scientific community. An extremely important role of the vesicle transduction has been established for almost all processes in a living body. Not only profiles of protein and RNA expression in a cell, but also its secretome change during various pathologies, including cancer development. The enhanced secretion of vesicles by transformed cells is one important factor in creating a special microenvironment that favors tumor progression. At present, a role of exosomes has been demonstrated for such important processes as an epithelial-mesenchymal transition, angiogenesis, metastatic niche formation, chemotherapeutic resistance, and interaction with the immune system. The special biological role of the extracellular vesicles and their basic differences depend on their molecular composition. Therefore, special protein and lipid markers are responsible for a vesicular targeted delivery with information due to the preferable interaction with cells of a definite type. The exosomes of cancer cells can facilitate apoptosis or growth of neighboring malignant cells depending on the exosome composition. These and other special features of the extracellular vesicles make studies of their composition and role especially interesting and attract significant attention from researchers. Despite the rapid progress in this field, there are still many unresolved problems, such as a search for specific markers which allow identification of different types of vesicles or vesicles secreted by distinct cells, as well as screening of vesicular markers of cancers and other diseases that are associated with disorders in a functioning immune system. This review is mainly focused on the role of intercellular vesicular transport of bioorganic molecules in cancer progression. We believe that a successful treatment of oncological diseases is impossible without an understanding of the intercellular communication of both cancer cells between each other and with other systems of an organism and with a concept of an active participation of the cell-secreted vesicles in this process.

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Abbreviations

АBs:

apoptotic bodies

EV:

an extracellular vesicle

MVBs:

multivesicular bodies

ADAM10:

the disintegrin and metalloproteinase domain 10

AKT:

the alpha serine/threonine-protein kinase

Bcl-2:

the B-cell lymphoma 2

Bim:

the Bcl-2-like protein 11

BIRC5:

the baculoviral inhibitor of apoptosis repeat-containing 5

Bsx:

the brain-specific homeobox protein homolog

CXCR2:

the C-X-C chemokine receptor type 2

СD:

a cluster of differentiation

EDH1:

the EH domain-containing protein 1, where EH is the EPS15 homologue and EPS15 is the epidermal growth factor receptor substrate 15

EGF:

the epidermal growth factor

EGFR:

the receptor of the epidermal growth factor

ESCRT:

the endosomal sorting complex required for transport

EMMPRIN:

the extracellular matrix metalloproteinase inducer

EpCAM:

an epithelial cell adhesion molecule

EPS8L:

the epidermal growth factor receptor kinase substrate 8-like protein 2

ERG:

the ETS-related gene

ETS:

erythroblast transformation-specific

ERK:

extracellular signal–regulated kinases

GPC1:

glypican 1

HER-2:

the human epidermal growth factor receptor 2

HSP:

heat shock proteins

IL:

interleukin

JNK:

the c-Jun N-terminal kinase

L1CAM:

the L1 cell adhesion molecule

MAPK:

the mitogen-activated protein kinase

MHC:

the major histocompatibility complex

miR:

a micro-RNA

MLCK:

the myosin light-chain kinase

NFκB:

the nuclear factor kappa-lightchain- enhancer of activated B cells

PCA:

a prostate cancer antigen

PDCD4:

the programmed cell death protein 4

PI3:

phosphoinositide 3-kinase

PLD:

phospholipase D

PTEN:

phosphatase and tensin homolog deleted on chromosome 10

Rab:

the Ras-related protein in brain

Ras:

the rat sarcoma

Rho:

the ρ Greek letter

ROCK1:

the rho-associated, coiled-coil-containing protein kinase 1

Src:

sarcoma

TGF:

the transforming growth factor

TMPRSS:

the transmembrane serine protease 2

TSG101:

the tumor susceptibility gene 101

TYRP-2:

the tyrosinase-related protein 2

VEGF:

the vascular endothelial growth factor

Vps4:

the vacuolar protein sorting- associated protein 4

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Authors and Affiliations

  1. Shemyakin–Ovchinnikov Institute of Bioorganic Chemistry of the Russian Academy of Sciences, Moscow GSP-7, 117997, Russia

    N. A. Logvina, V. O. Shender, G. P. Arapidi & T. D. Holina

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  1. N. A. Logvina
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  2. V. O. Shender
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  3. G. P. Arapidi
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  4. T. D. Holina
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Correspondence to N. A. Logvina.

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Original Russian Text © N.A. Logvina, V.O. Shender, G.P. Arapidi, T.D. Holina, 2018, published in Bioorganicheskaya Khimiya, 2018, Vol. 44, No. 2, pp. 113–125.

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Logvina, N.A., Shender, V.O., Arapidi, G.P. et al. A Role of Vesicular Transduction of Intercellular Signals in Cancer Development. Russ J Bioorg Chem 44, 129–139 (2018). https://doi.org/10.1134/S1068162018010120

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