Russian Journal of Bioorganic Chemistry

, Volume 44, Issue 2, pp 140–149 | Cite as

Regulation of Natural Rubber Biosynthesis by Proteins Associated with Rubber Particles

  • A. Yu. Amerik
  • Yu. Tc. Martirosyan
  • I. V. Gachok
Review Article

Abstract

Natural rubber, cis-1,4-polyisoprene, is an essential raw material used in thousands of products, many of which are absolutely necessary for medical purposes. Natural rubber is obtained from latex, an aqueous emulsion present in the laticiferous vessels of the natural rubber-producing plants. Hevea brasiliensis (the Brazilian rubber tree) currently is the only commercially important source of natural rubber. H. brasiliensis crops have very little genetic variability, leaving rubber plantations at risk of serious pathogenic attacks. In addition, repeated exposure to residual proteins in latex products derived from H. brasiliensis have led to serious and widespread allergic (type I) hypersensitivity. Therefore, identification of alternative sources of natural rubber is a very important biotechnological task. Potentially, Russian dandelion (Taraxacum kok-saghyz) may be such an alternative because significant amounts of natural rubber are produced in its root system. However, H. brasiliensis is a more efficient producer of natural rubber than T. kok-saghyz. Thus, improvement of rubber biosynthesis in plants is a first-priority problem of modern biotechnology. In this review, we describe proteins that may increase the concentration of natural rubber in laticiferous vessels of T. kok-saghyz and its close relative Taraxacum brevicorniculatum, when overexpressed in the plants. These proteins, cis-prenyltransferases, rubber transferase activator, and small rubber particle proteins, are directly involved in synthesis of the polyisoprene chain. We also analyze the effects of their expression levels on the production of natural rubber in vivo.

Keywords

natural rubber rubber particles Taraxacum kok-saghyz cis-prenyltransferases rubber transferase activator small rubber particle proteins 

Abbreviations

Ac-CоА

acetyl coenzyme A

APP

allylpyrophosphate

CPT1–3

cis-prenyltransferases 1–3

DMAPP

1,1-dimethylallylpyrophosphate

FPP

farnesyl pyrophosphate

HMG-CoA

3-hydroxy-3-methylglutaryl coenzyme A

IPP

iso-pentenylpyrophosphate

HRT1 and HRT2

cis-prenyltransferases 1 and 2

NgBR

Nogo-B receptor

TbRTA

T. brevicorniculatum cis-prenyltransferase activator

RNAi

RNA interference

SRPP

small rubber particle-associated protein

EPR

endoplasmic reticulum

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Copyright information

© Pleiades Publishing, Ltd. 2018

Authors and Affiliations

  • A. Yu. Amerik
    • 1
  • Yu. Tc. Martirosyan
    • 1
    • 2
  • I. V. Gachok
    • 1
    • 3
  1. 1.Emanuel Institute of Biochemical PhysicsRussian Academy of SciencesMoscowRussia
  2. 2.All-Russia Institute of Agricultural BiotechnologyMoscowRussia
  3. 3.Department of ChemistryMoscow State UniversityMoscowRussia

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