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DNA Repair Enzymes as Promising Targets in Oncotherapy

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Abstract

DNA repair is a complicated process that occurs due to a network of different pathways and mechanisms for correction of DNA damages during the normal DNA biosynthesis and under the influence of external and internal factors. The study of these mechanisms and their regulation is closely related to both diagnostics and the search for ways of treating various diseases, including oncological ones. Malignant neoplasms are one of the three most widespread diseases in the world, which unfortunately often become the reason for a lethal outcome. Traditional cancer therapy aims to the DNA damage in malignant cells, and its result depends on the efficiency of the repair systems. In many cancer cells, the individual DNA repair enzymes are overexpressed, which promotes the resistance of these tumors to the therapy. On the other hand, defects in the DNA repair systems in cancer cells allow researchers to find both appropriate biomarkers for diagnostics and targets for the development of the specific and effective therapy. Currently, DNA repair inhibitors are being actively developed in order to increase the sensitivity of the tumor cells to traditional chemotherapy. The principle of synthetic lethality is used to create cell-specific drugs and to improve the effectiveness of the treatment. In this review, we discuss the current state of research and prospects for the development of inhibitors for five important DNA repair enzymes.

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Abbreviations

BER:

base excision repair

PARP1/2:

poly(ADP-ribose)polymerase 1/2

PAR:

poly(ADP-ribose)

BRCA:

from BReast CAncer, tumor suppressor genes

BRCT domain:

C-terminal BRCT1 domain that is found in cell cycle control proteins in response to DNA damage and is responsible for protein-protein interactions

XRCC:

from X-ray repair cross-complementing protein, complementation group protein, that provide the cell sensitivity to X-ray

PTEN:

from Phosphatase and TENsin homologue deleted on chromosome 10, phosphatase with double substrate specificity

TDP1:

tyrosyl-DNA-phosphodiesterase 1

TOP 1:

topoisomerase 1

SCAN1:

spinocerebellar ataxia with neuropathy

APE1:

apurinic/apyrimidinic endonuclease 1, AP site, apurinic/apyrimidinic site

Polβ:

DNA polymerase β

dRP:

2′-deoxyriboso-5′-phosphate.

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Authors and Affiliations

  1. Institute of Chemical Biology and Fundamental Medicine, Siberian Branch of the Russian Academy of Sciences, Novosibirsk, 630090, Russia

    A. L. Zakharenko, N. A. Lebedeva & O. I. Lavrik

  2. Novosibirsk State University, Novosibirsk, 630090, Russia

    O. I. Lavrik

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  1. A. L. Zakharenko
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Original Russian Text © A.L. Zakharenko, N.A. Lebedeva, O.I. Lavrik, 2018, published in Bioorganicheskaya Khimiya, 2018, Vol. 44, No. 1, pp. 3–11.

The paper is based on the materials presented for the VIII Russian symposium “Proteins and Peptides”; September 18–22, 2017, Moscow.

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Zakharenko, A.L., Lebedeva, N.A. & Lavrik, O.I. DNA Repair Enzymes as Promising Targets in Oncotherapy. Russ J Bioorg Chem 44, 1–18 (2018). https://doi.org/10.1134/S1068162017060140

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