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Preparation and Biodistribution of 99mTc-Trazodone as a Brain Imaging Probe

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Abstract

Trazodone was labeled with 99mTc by indirect method. More than 97% radiochemical yield was reached under the following optimized conditions: 100 µg of Trazodone, pH 7, 10 mg of glucoheptonate, 35 µg of stannous chloride, 185 MBq of 99mTc eluate, 20 min, room temperature. The in vitro stability and also the retention of the complex in the brain tissue allow the use of this complex as a potential brain imaging agent.

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Authors and Affiliations

  1. Hot Laboratories Centre, Atomic Energy Authority, P.O. Box 13759, Cairo, Egypt

    H. A. El-Sabagh & H. M. Talaat

  2. Department of Chemistry, Faculty of Science, Ain-Shams University, Cairo, Egypt

    M. S. A. Abdel-Mottaleb

Authors
  1. H. A. El-Sabagh
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  2. H. M. Talaat
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  3. M. S. A. Abdel-Mottaleb
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Correspondence to H. A. El-Sabagh.

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El-Sabagh, H.A., Talaat, H.M. & Abdel-Mottaleb, M.S.A. Preparation and Biodistribution of 99mTc-Trazodone as a Brain Imaging Probe. Radiochemistry 61, 93–98 (2019). https://doi.org/10.1134/S1066362219010144

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  • DOI: https://doi.org/10.1134/S1066362219010144

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