Skip to main content
SpringerLink
Log in

Effect of Eluting the 99Mo/99mTc Generator More than Once in 24 h on the Efficiency of the 99mTc-MIBI Complex

  • Published:
Radiochemistry Aims and scope

Abstract

The effect of heating time, heating temperature, the amount of activity added to the MIBI kit, and the age of the formulated kit on the radiochemical purity of 99mTc-MIBI complex is demonstrated. 1-mCi (37-MBq) 99mTc-MIBI samples were prepared using the standard boiling water bath procedure. Qualitative and quantitative studies were done for the samples. The radiochemical purity of 99mTc that had been eluted from two types of 99Mo/99mTc generators was studied. The efficiency of 99mTc-MIBI samples was tested based on these studies. The results obtained show that eluting 99Mo/99mTc generators more than once in 24 h can lead to increased medical risks in patients with myocardial infarction.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Similar content being viewed by others

References

  1. Shojaei, M.R., Hajizadeh, M., and Khorasanchi, A., Iran. J. Radiat. Safety Meas., 2015, vol. 3, no. 4, pp. 15–18. URL: https://doi.org/rsm.kashanu.ac.ir/article-1-154-en.html.

    Google Scholar 

  2. Kamen, M.D., Science, 1963, vol. 140, no. 3567, pp. 584–590. DOI: https://doi.org/10.1126/SCIENCE.140.3567.584.

    Article  PubMed  Google Scholar 

  3. Choppin, G. and Rydberg, J., Nuclear Chemistry: Theory and Applications, Oxford: Pergamon, 1980.

    Google Scholar 

  4. Khamis, S.B. and Ab-Wahid, M., in Int. Symp. on Modern Trends in Radiopharmaceuticals for Diagnosis and Therapy, Lisbon: IAEA, 1998, pp. 249–255.

    Google Scholar 

  5. Vučina, J.L., Facta Univ. Ser. Phys., Chem. Technol., 2001, vol. 2, no. 3,: pp. 125–130.

    Google Scholar 

  6. Perrier, C. and Segre, E., Nature, 1937, vol. 140, pp. 193–194.

    Article  CAS  Google Scholar 

  7. Richards, P., Technetium-99m: The Early Days, New York: BNL, 1989.

    Google Scholar 

  8. Tucker, W.D., Greene, M.W., Weiss, A.J., and Murrenhoff, A., Methods of Preparation of Some Carrier-Free Radioisotopes Involving Sorption on Alumina, US AEC, 1958. DOI: https://doi.org/10.2172/4305138.

    Book  Google Scholar 

  9. Richards, P., Tucker, W.D., and Srivastava, S.C., Int. J. Appl. Radiat. Isot., 1982, vol. 33, no. 10, pp. 793–799. DOI: https://doi.org/10.1016/0020-708X(82)90120-X.

    Article  CAS  PubMed  Google Scholar 

  10. Dilworth, J.R. and Parrott, S.J., Chem. Soc. Rev., 1998, vol. 27, pp. 43–55.

    Article  CAS  Google Scholar 

  11. Design Principles of the 99 Mo → 99m Tc Radionuclide Generator, https://doi.org/nucleus.iaea.org/HHW/Radiopharmacy/VirRad/Eluting_the_Generator/Generator_Module/Design_principles/index.html.

  12. Momennezhad, M. Zakavi, S.R., and Sadeghi, R., Iran. J. Radiat. Res., 2010, vol. 8, no. 1, pp. 31–35.

    Google Scholar 

  13. Pauwels, E.K.J., Welling, M.M., Feitsma, R.I.J, et al., Nucl. Med. Biol., 1993, vol. 20, no. 7, pp. 825–833.

    Article  CAS  PubMed  Google Scholar 

  14. Rodriguez-puig, D., Piera, C., Fuster, D., et al., J. Label. Compd. Radiopharm., 2006, vol. 49, no. 13, pp. 1171–1176.

    Article  CAS  Google Scholar 

  15. Fritzberg, A.R. and Beaumier, P.L., J. Nucl. Med., 1992, vol. 33, no. 3, pp. 394–397.

    CAS  PubMed  Google Scholar 

  16. Tasdelen, B., J. Radioanal. Nucl. Chem., 2011, vol. 290, no. 2, pp. 283–287. DOI: https://doi.org/10.1007/s10967-011-1311-8.

    Article  CAS  Google Scholar 

  17. Hung, J.C., Wilson M.E., Brown, M.L., and Gibbons, R.J., J. Nucl. Med., 1991, vol. 32, pp. 2162–2168.

    CAS  PubMed  Google Scholar 

  18. Norenberg, J.P., Vaidya, M.P., Hladik, W.B., and Pathak, D.R., J. Nucl. Med. Technol., 2005, vol. 33, pp. 34–41.

    CAS  PubMed  Google Scholar 

  19. Djokić, D., Janković, D., and Pirmettis, I., Abstracts of Papers, 13th Eur. Symp. on Radiopharmacy and Radiopharmaceuticals, Lucca (Italy), 2006, p. 64.

    Google Scholar 

  20. Doroudi, A., Saadati, S.M., Hassanpour, H., et al., J. Radioanal. Nucl. Chem., 2013, vol. 298, no. 2, pp. 1185–1190. DOI: https://doi.org/10.1007/s10967-013-2559-y.

    Article  CAS  Google Scholar 

  21. Piwnica-Worms, D., Kronauge, J.F., Holman, B.L., et al., Invest. Radiol., 1989, vol. 24, pp. 25–29.

    Article  CAS  PubMed  Google Scholar 

  22. Canby, R.C., Silber, S., and Pohost, G.M., Circulation, 1990, vol. 81, pp. 289–296.

    Article  CAS  PubMed  Google Scholar 

  23. Fukushima, K., Mamosa, M., Kondo, C., et al., Nucl. Med. Biol., 2010, vol. 37, pp. 1005–1012.

    Article  CAS  PubMed  Google Scholar 

  24. Moller, J., Warwick, J., and Bouma, H., Cardiovasc. J. South Afr., 2005, vol. 16, pp. 95–101.

    CAS  Google Scholar 

  25. Fallahi, B., Beiki, D., Fard-Esfahani, A., et al., Hell. J. Nucl. Med., 2010, vol. 13, pp. 246–252.

    PubMed  Google Scholar 

  26. Park Y.H., Ferrante, J., Robinson, R.E., and Arvay, K., J. Nucl. Med. Technol., 1999, vol. 27, pp. 298–300.

    CAS  PubMed  Google Scholar 

  27. Vecchio, S.D. and Salvatore, M., Eur. J. Nucl. Med. Mol. Imag., 2004, vol. 31, pp. S88–S96.

    Article  Google Scholar 

  28. Spanu, A., Falchi, A, Manea, A., et al., J. Nucl. Med., 2004, vol. 45, pp. 40–48.

    PubMed  Google Scholar 

  29. Arsalan, N., Ilgan, S., Urhan, M., et al., Turk. J. Endocrinol. Metab., 1999, vol. 2, pp. 47–52.

    Google Scholar 

  30. Dirlik, A., Burak, Z., Goksel, T., et al., Ann. Nucl. Med., 2002, vol. 16, pp. 103–108.

    Article  CAS  PubMed  Google Scholar 

  31. Akgun, A., Cok, G., Karapolat, I., et al., Ann. Nucl. Med., 2006, vol. 20, pp. 269–275.

    Article  PubMed  Google Scholar 

  32. Williams, C.C., Kereiakes, J.G., and Grossman, L.W., Radiology, 1981, vol. 138, pp. 445–448.

    Article  CAS  PubMed  Google Scholar 

  33. Da Silva, C., Riberio, B.S., Souza, W.O., et al., Application of bioassay techniques to evaluate 99Mo incorporation in nuclear medicine patients, Int. Nuclear Atlantic Conf. INAC 2007, Santos, SP (Brazil), Sept. 30–Oct. 5, 2007.

    Google Scholar 

  34. Fatima, N., Zaman, M., Niayz, K., et al., Pak. J. Radiol., 2008, vol. 18, pp. 20–21.

    Google Scholar 

  35. Doroudi, A., Saraji, F., Erfani, M., et al., J. Appl. Pharm. Sci., 2016, vol. 6, no. 11, pp. 126–134.

    Article  CAS  Google Scholar 

  36. Moore, P.W., J. Nucl. Med., 1984, vol. 25, no. 4, pp. 499–502.

    CAS  PubMed  Google Scholar 

  37. Kowalsky, R.J., Technetium Radiopharmaceutical Chemistry, New Mexico: Univ. of New Mexico Health Sciences Center, 2006.

    Google Scholar 

  38. Non-HEU Production Technologies for Molybdenum-99 and Technetium-99m, Vienna: IAEA, 2013.

  39. Piwnica-Worms, D, Chiu, M.L., Budding, M., et al., Cancer Res., 1993, vol. 53, pp. 977–984.

    CAS  PubMed  Google Scholar 

  40. Dantas, B.M., Dantas, A.L.A., Marques, F.L.N., et al., Braz. Arch. Biol. Technol., 2005, vol. 48, no. spe2, pp. 215–220. DOI: https://doi.org/10.1590/S1516-89132005000700032.

    Article  Google Scholar 

  41. Kowalsky, R.J. and Falen, S.W., Radiopharmaceuticals in Nuclear Pharmacy and Nuclear Medicine, Washington: Am. Pharm. Assoc., 2004.

    Google Scholar 

  42. Verduyck, T., Kieffer, D., Huyghe, D., et al., J. Pharm. Biomed. Anal., 2003, vol. 31, pp. 669–678.

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Yasooj Branch, Islamic Azad University, Yasooj, Iran

    S. H. Hassanpour

  2. Department of Toxicology, Faculty of Pharmacy, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran

    M. A. Dehghani

  3. Department of Medical Physics, Faculty of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran

    R. Elhamasl

  4. Faculty of Civil Engineering, University of Tehran, Tehran, Iran

    R. Lalehzari

Authors
  1. S. H. Hassanpour
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. M. A. Dehghani
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. R. Elhamasl
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. R. Lalehzari
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to S. H. Hassanpour.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Hassanpour, S.H., Dehghani, M.A., Elhamasl, R. et al. Effect of Eluting the 99Mo/99mTc Generator More than Once in 24 h on the Efficiency of the 99mTc-MIBI Complex. Radiochemistry 61, 73–80 (2019). https://doi.org/10.1134/S1066362219010119

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1134/S1066362219010119

Keywords

Search

Navigation