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Studying the Sensitivity of Graphene for Biosensor Applications

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Abstract

We have studied the response of graphene-film-based chips on SiC substrates (the relative change in the chip resistance) to coming into contact with fluorescein (C20H12O5) in a wide range of its concentrations in a phosphate-buffered saline solution: from 1 × 10–3 to 1 × 104 ng/mL (seven orders of magnitude). Fluorescein detection seems to be a simple and cheap model experiment to study the sensory ability of graphene in the way of biochips manufacturing. It has been shown that chips with wide terraces on a surface with a step width of about 1000 nm and heights of up to 5 nm made it possible to construct the calibration dependences of chip response on fluorescein concentration.

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ACKNOWLEDGMENTS

The authors are grateful to P.A. Dement’ev for AFM measurements.

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Authors and Affiliations

  1. Nitride Crystals, Inc., Richmond, United States

    A. S. Usikov & Yu. N. Makarov

  2. St. Petersburg National Research University ofInformation Technologies, Mechanics, and Optics University (ITMO), 197101, St. Petersburg, Russia

    A. S. Usikov & A. V. Zubov

  3. Ioffe Physical Technical Institute, Russian Academy of Sciences, 194021, St. Petersburg, Russia

    S. P. Lebedev, I. S. Barash & A. A. Lebedev

  4. Nitride Crystals Group, 194156, St. Petersburg, Russia

    A. D. Roenkov & I. S. Barash

  5. Aalto University, Espoo, Finland

    S. V. Novikov

  6. Herzen State Pedagogical University, 191186, St. Petersburg, Russia

    M. V. Puzyk

Authors
  1. A. S. Usikov
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  2. S. P. Lebedev
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  3. A. D. Roenkov
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  4. I. S. Barash
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  5. S. V. Novikov
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  6. M. V. Puzyk
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  7. A. V. Zubov
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  8. Yu. N. Makarov
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  9. A. A. Lebedev
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Corresponding author

Correspondence to A. S. Usikov.

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The authors declare that they have no conflict of interest.

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Translated by G. Dedkov

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Usikov, A.S., Lebedev, S.P., Roenkov, A.D. et al. Studying the Sensitivity of Graphene for Biosensor Applications. Tech. Phys. Lett. 46, 462–465 (2020). https://doi.org/10.1134/S1063785020050296

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  • DOI: https://doi.org/10.1134/S1063785020050296

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