It was shown that the level of nitric oxide metabolites in the blood plasma of people with essential arterial hypertension (EAH) is significantly higher than that of healthy donors. This pattern did not depend on the stage of the disease, but on the age of the subjects, as well as on whether patients with cardio-selective β-adrenoreceptor blockers take them or not. It was established that an increase in the level of nitrites and nitrates in the blood of patients with EAH was accompanied by an increase in the level of transcripts of the NOS2 gene in the peripheral blood leukocytes (PBL), while the mRNA content of the NOS3 gene in the PBL patients was slightly lower than that of healthy donors.
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This study was supported by the federal budget for performance of a state assignment of the Federal Research Center, Karelian Research Center, Russian Academy of Sciences, project no. 0221-2017-0049.
Conflict of interest. The authors declare that they have no conflict of interest.
Statement of compliance with standards of research involving humans as subjects. All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards. Informed consent was obtained from all individual participants involved in the study.
Translated by P. Vikhreva
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Topchieva, L.V., Balan, O.V., Korneva, V.A. et al. The Nitric Oxide Metabolite Level and NOS2 and NOS3 Gene Transcripts in Patients with Essential Arterial Hypertension. Biol Bull Russ Acad Sci 47, 247–252 (2020). https://doi.org/10.1134/S1062359020010161