Mechanism of reaction of selenium elimination in diacetophenonyl selenide under the action of reduced glutathione
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Products of reaction between the organoselenium xenobiotic, diacetophenonyl selenide (1,5-diphenyl-3-selenapenta-1,5-dione), and reduced glutathione at different molar ratios and pH values were studied by HPLC and TLC. Reaction intermediates, S-(acetophenylselenyl)glutathione and glutathione selenodisulfide, and reaction products, acetophenone and hydroselenide anion, were detected. The reaction scheme proposed earlier was confirmed.
Keywordsdiacetophenonyl selenide S-(acetophenylselenyl)glutathione reduced glutathione acetophenone hydroselenide anion HPLC TLC
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