Journal of Analytical Chemistry

, Volume 72, Issue 7, pp 739–744 | Cite as

Mechanism of reaction of selenium elimination in diacetophenonyl selenide under the action of reduced glutathione

  • P. A. Poluboyarinov
  • P. P. Leshchenko
  • I. Ya. Moiseeva
  • S. G. Kolesnikova
  • N. B. Epshtein
Articles
  • 36 Downloads

Abstract

Products of reaction between the organoselenium xenobiotic, diacetophenonyl selenide (1,5-diphenyl-3-selenapenta-1,5-dione), and reduced glutathione at different molar ratios and pH values were studied by HPLC and TLC. Reaction intermediates, S-(acetophenylselenyl)glutathione and glutathione selenodisulfide, and reaction products, acetophenone and hydroselenide anion, were detected. The reaction scheme proposed earlier was confirmed.

Keywords

diacetophenonyl selenide S-(acetophenylselenyl)glutathione reduced glutathione acetophenone hydroselenide anion HPLC TLC 

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Copyright information

© Pleiades Publishing, Ltd. 2017

Authors and Affiliations

  • P. A. Poluboyarinov
    • 1
  • P. P. Leshchenko
    • 1
  • I. Ya. Moiseeva
    • 2
  • S. G. Kolesnikova
    • 3
  • N. B. Epshtein
    • 3
  1. 1.Penza State University of Architecture and ConstructionPenzaRussia
  2. 2.Penza State UniversityPenzaRussia
  3. 3.National Research Nuclear University MEPhIObninskRussia

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