Mechanism of reaction of selenium elimination in diacetophenonyl selenide under the action of reduced glutathione
- 36 Downloads
Products of reaction between the organoselenium xenobiotic, diacetophenonyl selenide (1,5-diphenyl-3-selenapenta-1,5-dione), and reduced glutathione at different molar ratios and pH values were studied by HPLC and TLC. Reaction intermediates, S-(acetophenylselenyl)glutathione and glutathione selenodisulfide, and reaction products, acetophenone and hydroselenide anion, were detected. The reaction scheme proposed earlier was confirmed.
Keywordsdiacetophenonyl selenide S-(acetophenylselenyl)glutathione reduced glutathione acetophenone hydroselenide anion HPLC TLC
Unable to display preview. Download preview PDF.
- 4.Blinokhvatov, A.F., Doctoral (Chem.) Dissertation, Saratov: Saratov State Univ., 1993.Google Scholar
- 5.Drevko, B.I., Antipov, V.A., Zhukov, O.I., et al., RF Patent 2051681, Byull. Izobret., 2001, no. 1.Google Scholar
- 8.Nazarenko, I.I. and Ermakov, A.N., Analiticheskaya khimiya selena i tellura (Analytical Chemistry of Selenium and Tellurium), Moscow: Nauka, 1971.Google Scholar
- 10.Novikov, A.V., Bublyaev, R.A., Krasnov, N.V., Koz’min, Yu.P., Kuraeva, T.E., and Mirgorodskaya, O.A., Nauchn. Priborostr., 2007, vol. 17, no. 4, p. 29.Google Scholar