Abstract
An HPLC−HRMS method for the detection of the benzofuran analog of amphetamine and its metabolites in human urine using both library search and target search of the most probable metabolites based on their calculated accurate weights and fragmentation regularities is proposed. The proposed method is confirmatory. Gas chromatography–electron impact mass spectrometry with library search is proposed as the main screening method.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Welter, J., Kavanagh, P., Meyer, M.R., and Maurer, H.H., Anal. Bioanal. Chem., 2015, vol. 407, p. 1371.
Welter, J., Brandt, S.D., Kavanagh, P., and Maurer, H.H., Anal. Bioanal. Chem., 2015, vol. 407, p. 3457.
Creveling, C.R., Methyltransferases, ch. 13 of Enzyme Systems that Metabolise Drugs and Other Xenobiotics, Ioannides, C., Ed., Chichester: Wiley, 2001, p. 485.
Labutin, A.V. and Temerdashev, A.Z., Mass-Spektrom., 2015, vol. 12, no. 1, p. 30.
Grigoryev, A., Kavanagh, P., and Melnik, A., Drug Test. Anal., 2012, vol. 4, no. 2, p. 519.
Temerdashev, A.Z., Grigor’ev, A.M., and Rybal’chenko, I.V., J. Anal. Chem., 2014, vol. 69, no. 9, p. 817.
Sobolevsky, T., Prasolov, I., and Rodchenkov, G., Drug Test. Anal., 2012, vol. 4, no. 10, p. 745.
Sobolevskii, T.G., Prasolov, I.S., and Rodchenkov, G.M., Mass-Spektrom., 2010, vol. 7, no. 3, p. 175.
Zhang, Q., Ma, P., Cole, R.B., and Wang, G., Anal. Bioanal. Chem., 2006, vol. 386, no. 5, p. 1345.
Wintermeyer, A., Möller, I., Thevis, M., Jübner, M., Beike, J., Rothschild, M.A., and Bender, K., Anal. Bioanal. Chem., 2010, vol. 398, no. 5, p. 2141.
Gambaro, V., Arnoldi, S., Bellucci, S., Casagni, E., Dell’Acqua, L., Fumagalli, L., Pallavicini, M., Roda, G., Rusconi, C., and Valoti, E., J. Chromatogr. B: Anal. Technol. Biomed. Life Sci., 2014, vol. 957, p. 68.
Castro, A., Tarelho, S., Silvestre, A., and Teixeira, H.M., J. Forensic Leg. Med., 2012, vol. 12, no. 2, p. 77.
Scheidweiler, K. and Huestis, M., J. Chromatogr. A, 2014, vol. 1327, p. 105.
Chimalakonda, K.C., Moran, C.L., Kennedy, P.D., Kennedy, P.D., Endres, G.W., Uzieblo, A., Dobrowolski, P.J., Kim, E., Lapoint, F.J., Nelson, L.S., Hoffman, R.S., James, L.P., Radominska-Pandya, A., and Moran, J.H., Anal. Chem., 2011, vol. 83, no. 16, p. 6381.
Coulter, C., Garnier, M., and Moore, C., J. Anal. Toxicol., 2011, vol. 35, no. 7, p. 424.
Strano-Rossi, S., Anzillotti, L., Castrignano, E., Romolo, F.S., and Chiarotti, M., J. Chromatogr. A, 2012, vol. 1258, p. 37.
Kneisel, S., Auwarter, V., and Kempf, J., Drug Test. Anal., 2013, vol. 5, no. 8, p. 657.
Shitov, L.N., Labutin, A.V., Kataev, S.S., Pechnikov, A.L., Kolosova, M.V., Shabrov, V.N., Dzhurko, Yu.A., and Ershov, M.B., Butlerov. Chteniya, 2014, vol. 38, no. 4, p. 94.
Adamowicz, P., Zuba, D., and Byrska, B., Forensic Sci. Int., 2014, vol. 245, p. 126.
Author information
Authors and Affiliations
Corresponding author
Additional information
Original Russian Text © A.V. Labutin, A.Z. Temerdashev, 2017, published in Zhurnal Analiticheskoi Khimii, 2017, Vol. 72, No. 7, pp. 650–656.
Rights and permissions
About this article
Cite this article
Labutin, A.V., Temerdashev, A.Z. Identification of (2-aminopropyl)benzofuran and its metabolites in human urine. J Anal Chem 72, 770–776 (2017). https://doi.org/10.1134/S1061934817070085
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1134/S1061934817070085