Journal of Analytical Chemistry

, Volume 72, Issue 3, pp 264–271 | Cite as

Application of polyaniline–multiwalled carbon nanotubes composite fiber for determination of benzaldehyde in injectable pharmaceutical formulations by solid-phase microextraction GC–FID using experimental design

  • Vahideh Masoumi
  • Ali MohammadiEmail author
  • Mohammad Reza Khoshayand
  • Mehdi Ansari


A polyaniline–multiwalled carbon nanotubes composite fiber was electrodeposited onto a platinum wire using cyclic voltammetry. This fiber was used for headspace solid-phase microextraction combined with gas chromatography and flame ionization detector of trace levels of benzaldehyde in some injectable pharmaceutical formulations. Three solid-phase microextraction parameters including temperature, time and stirring rate were investigated simultaneously using a three-level-three-factor Box–Behnken as experimental design on the extraction capability. The as-made fiber has a lifetime of over 300 extractions without any obvious decline in extraction efficiency. At the optimum conditions (extraction temperature 60°C, extraction time 15 min, stirring rate 700 rpm), the method displays excellent linearity over the concentration range of 25–1000 ng/mL of benzaldehyde with RSD values ranging from 1.0 to 6.8%. The limits of quantitation and detection were 25 and 10 ng/mL, respectively.


benzaldehyde experimental design solid-phase microextraction GC-FID polyaniline–multiwalled carbon nanotubes 


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  1. 1.
    Rowe, R.C., Sheskey, P.J., and Quinn, M.E., Handbook of Pharmaceutical Excipients, London: Pharmaceutical, 2009, 6th ed.Google Scholar
  2. 2.
    Urakami, K., Kobayashi, C., Miyazaki, Y., Nishijima, K., Yoshimura, Y., and Hashimoto, K., Chem. Pharm. Bull., 2000, vol. 48, p. 1299.CrossRefGoogle Scholar
  3. 3.
    Saiki, J.H., Thompson, S., Smith, F., and Atkinson, R., Cancer, 1972, vol. 29, p. 370.CrossRefGoogle Scholar
  4. 4.
    Hahn, A.F., Feasby, T.E., and Gilbert, J.J., Neurology, 1983, vol. 33, p. 1032.CrossRefGoogle Scholar
  5. 5.
    Kazemifard, A.G., Moore, D.E., and Mohammadi, A., J. Pharm. Biomed. Anal., 2002, vol. 30, p. 257.CrossRefGoogle Scholar
  6. 6.
    United States Pharmacopeia 35, The United States Pharmacopeial Convention, Rockville, MD, 2012, vol. 1, p. 1713.Google Scholar
  7. 7.
    British Pharmacopoeia, London: Medicines and Healthcare Products Regulatory Agency, 2012, vol. 1, p. 250.Google Scholar
  8. 8.
    Mohammadi, A., and Kebriyaeezadeh, A., J. Pharm. Biomed. Anal., 2003, vol. 31, p. 685.CrossRefGoogle Scholar
  9. 9.
    Sen, I., Shandil, A., and Shrivastava, V.S., Pharm Lett., 2011, vol. 3, p. 218.Google Scholar
  10. 10.
    Rizk, M., Ibrahim, F., Hefnawy, M., and Nasr, J.J., Acta Pharm., 2007, vol. 57, p. 231.CrossRefGoogle Scholar
  11. 11.
    Cavrini, V., Di Pietra, A.M., Raggi, M.A., and Sarti, R., J. Pharm. Biomed. Anal., 1987, vol. 5, p. 21.CrossRefGoogle Scholar
  12. 12.
    Pawliszyn, J., Handbook of Solid Phase Microextraction, London: Elsevier, 2012.Google Scholar
  13. 13.
    Hammami, B. and Driss, M.R., J. Anal. Chem., 2013, vol. 68, p. 671.CrossRefGoogle Scholar
  14. 14.
    Ye, Q., Zheng, D., and Chen, Z., J. Anal. Chem., 2011, vol. 66, p. 285.CrossRefGoogle Scholar
  15. 15.
    Chai, M., Tan, G., and Lal, A., Anal. Sci., 2008, vol. 24, p. 273.CrossRefGoogle Scholar
  16. 16.
    Wang, Y., Li, Y., Zhang, J., Xu, S., Yang, S., and Sun, C., Anal. Chim. Acta, 2009, vol. 646, p. 78.CrossRefGoogle Scholar
  17. 17.
    Kataoka, H., Anal. Sci., 2011, vol. 27, p. 893.CrossRefGoogle Scholar
  18. 18.
    Mohammadi, A., Mohammadi, S., Bayandori Moghaddam, A., Masoumi, V., and Walker, R.B., J. Chromatogr. Sci., 2014, vol. 52, p. 971.CrossRefGoogle Scholar
  19. 19.
    Mousavi, M., Noroozian, E., Jalali-Heravi, M., and Mollahosseini, A., Anal. Chim. Acta, 2007, vol. 581, p. 71.CrossRefGoogle Scholar
  20. 20.
    Mehdinia, A., Bashour, F., Roohi, F., and Jabbari, A., Microchim. Acta, 2012, vol. 177, p. 301.CrossRefGoogle Scholar
  21. 21.
    Karimi, A. and Alizadeh, N., Talanta, 2009, vol. 79, p. 479.CrossRefGoogle Scholar
  22. 22.
    Iijima, S., Nature, 1991, vol. 354, p. 56.CrossRefGoogle Scholar
  23. 23.
    Du, W., Zhao, F., and Zeng, B., J. Chromatogr. A, 2009, vol. 1216, p. 3751.CrossRefGoogle Scholar
  24. 24.
    Masoumi, V., Mohammadi, A., Amini, M., Khoshayand, M.R., and Dinarvand, R., J. Solid State Electrochem., 2014, vol. 18, p. 1763.CrossRefGoogle Scholar
  25. 25.
    Asadollahzadeh, H., Noroozian, E., and Maghsoudi, S., Anal. Chim. Acta, 2010, vol. 669, p. 32.CrossRefGoogle Scholar
  26. 26.
    Chen, L., Chen, W., Ma, C., Du, D., and Chen, X., Talanta, 2011, vol. 84, p. 104.CrossRefGoogle Scholar
  27. 27.
    Ghasemi, E. and Farahani, H., J. Chromatogr. A, 2012, vol. 1258, p. 16.CrossRefGoogle Scholar
  28. 28.
    Box, G.E.P., Hunter, J.S., and Hunter, W.G., Statistics for Experimenters, New York: Wiley, 2005, 2nd ed.Google Scholar
  29. 29.
    Ferreira, S.L.C., Bruns, R.E., Ferreira, H.S., Matos, G.D., David, J.M., and Brandão, G.C., da Silva, E.G.P., Portugal, L.A., dos Reis, P.S., Souza, A.S., and dos Santos, W.N.L., Anal. Chim. Acta, 2007, vol. 597, p. 179.CrossRefGoogle Scholar

Copyright information

© Pleiades Publishing, Ltd. 2017

Authors and Affiliations

  • Vahideh Masoumi
    • 1
  • Ali Mohammadi
    • 1
    • 2
    Email author
  • Mohammad Reza Khoshayand
    • 1
    • 3
  • Mehdi Ansari
    • 4
  1. 1.Department of Drug and Food Control, Faculty of PharmacyTehran University of Medical SciencesTehranIran
  2. 2.Nanotechnology Research Centre, Faculty of PharmacyTehran University of Medical SciencesTehranIran
  3. 3.Pharmaceutical quality assurance research Centre, Faculty of PharmacyTehran University of Medical SciencesTehranIran
  4. 4.Faculty of PharmacyKerman University of Medical SciencesKermanIran

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