Journal of Analytical Chemistry

, Volume 72, Issue 3, pp 256–263 | Cite as

Methods of determination of sulfur yperite–DNA adducts

  • O. I. Orlova
  • E. I. Savel’eva
  • G. V. Karakashev


A review of publications on methods for the determination of sulfur yperite adducts with DNA in different biological samples (whole blood, urine, organ and tissue homogenates) is presented. Methods of formation and structures of the most important adducts are considered. Methods of the isolation and hydrolysis of adducts with DNA from biological samples are summarized.


sulfur yperite biological samples biomarker metabolite DNA HPLC–mass spectrometry 


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Copyright information

© Pleiades Publishing, Ltd. 2017

Authors and Affiliations

  • O. I. Orlova
    • 1
  • E. I. Savel’eva
    • 1
  • G. V. Karakashev
    • 1
  1. 1.Scientific Research Institute of Hygiene, Professional Pathology, and Human EcologyFederal Medical Biological Agency of Russia, pos. Kuz’molovskiist. Kapitolovo, Leningrad oblastRussia

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