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Small-molecule analysis by surface-assisted laser desorption/ionization mass spectrometry

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Abstract

In order to meet the challenges facing modern chemistry, biology, and medicine, methods are required capable of performing rapid and reliable analysis of both individual compounds and complex mixtures at the molecular level. Matrix-assisted laser de-sorption/ionization mass spectrometry meets these requirements; however, some limitations complicate its application for the analysis of small molecules. Recently, small-molecule analysis has greatly progressed owing to development of surface-assisted laser desorption/ionization mass spectrometry involving approaches which combine the unique properties of nanostructured surface chemistry and morphology. This review examines such approaches and their specific application in small-molecule mass analysis.

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  1. Chuiko Institute of Surface Chemistry, National Academy of Sciences of Ukraine, ul. Generala Naumova 17, Kiev, 03164, Ukraine

    P. A. Kuzema

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The article was translated by the author.

Original Russian Text © P.A. Kuzema, 2010, published in Mass-spektrometria, No. 7(4), pp. 243–260.

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Kuzema, P.A. Small-molecule analysis by surface-assisted laser desorption/ionization mass spectrometry. J Anal Chem 66, 1227–1242 (2011). https://doi.org/10.1134/S1061934811130065

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