Association of MAOA-uVNTR Polymorphism with Subjective Well-Being in Men
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Quality of life and one’s subjective evaluation of one’s own happiness and well-being are the conventional focus of psychology and sociology. However, a genetic factor has recently been found to affect the subjective evaluation of well-being. The contribution of heredity to a personal level of happiness and life satisfaction has been estimated at 30–50% in twin studies. Individual genes associated with these traits have been identified, but the available data are rather discrepant. In this work, alleles of the monoamine oxidase A gene (MAOA) were tested for association with well-being components, such as happiness, health, dangers of living environment, and stress, in Russian men. Trait assessments were based on questionnaires filled out as part of the World Values Survey. It is shown that, among the uVNTR-3R allele carriers, the proportion of men who have high levels of stress, feel unhappy, and live in unsafe environments is lower. The results are discussed in the context of the gene plasticity concept, which provides a possible explanation for how expression of genes related to behavior changes in different environmental conditions.
KeywordsMAOA gene monoamine oxidase A subjective assessment of life satisfaction World Values Survey
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- 25.World Values Survey. http://www.worldvaluessurvey. org.Google Scholar
- 27.Shkolnikova, M., Shalnova, S., Shkolnikov, V.M., et al., Biological mechanisms of disease and death in Moscow: rationale and design of the survey on Stress Aging and Health in Russia (SAHR), BMC Public. Health, 2009, vol. 9, p. 293. doi 10.1186/1471-2458-9-293CrossRefPubMedPubMedCentralGoogle Scholar
- 36.Koenen, K.C., Aiello, A.E., Bakshis, E., et al., Modification of the association between serotonin transporter genotype and risk of posttraumatic stress disorder in adults by county-level social environment, Am. J. Epidemiol., 2009, vol. 169, no. 6, pp. 704–711. doi 10.1093/aje/kwn397CrossRefPubMedPubMedCentralGoogle Scholar