The solubility of cefixime disodium in seven pure solvents including ethanol, propan-2-ol, butan-1-ol, isoamyl alcohol, acetone, acetonitrile, and ethyl acetate was measured using a gravimetric method. The van’t Hoff equation, modified Apelblat equation and λh models were applied to correlate the experimental data. The modified Apelblat equation was found to give the best fit. Based on the van’t Hoff equation, the Gibbs energy of cefixime disodium was calculated, and the corrected data show that the dissolution process of cefixime disodium in all solvents is endothermic, non-spontaneous and enthalpy-driven.
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The work described in this paper received support from the National Natural Science Foundation of China (NSFC) (grant references: 21703126), the Shandong Keypoint Research and Development Plan (2018GSF117006 and 2019GSF109063).
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Yu, S., Xue, F.M. & Cheng, Y. Solubility of Cefixime Disodium in Seven Pure Solvents. Russ. J. Phys. Chem. 94, 1130–1135 (2020). https://doi.org/10.1134/S0036024420060333
- cefixime disodium
- thermodynamic model
- gravimetrical method