Biomedical engineering is the most promising field for the application of ferrogels as scaffolds for cell culturing in regenerative medicine, targeted drug delivery, and biosensorics. This study is focused on the contribution of ferric-oxide magnetic nanoparticles (MNPs) to the biocompatibility of ferrogels with human dermal fibroblasts. The results of experiments with polyacrylamide gels filled with MNPs are presented. These experiments demonstrate that, regardless of the mechanical and electrical characteristics of ferrogels, MNPs have a significant effect on the biological activity of cells.
This is a preview of subscription content, log in to check access.
Buy single article
Instant access to the full article PDF.
Price includes VAT for USA
Y. Li, G. Huang, X. Zhang, B. Li, Y. Chen, T. Lu, T. Lu, and F. Xu, “Magnetic hydrogels and their potential biomedical applications,” Adv. Funct. Mater. 23, 660–672 (2013).
S. Kennedy, C. Roco, A. Délerisa, P. Spoerri, C. Cezar, J. Weaver, H. Vandenburgh, and D. Mooney, “Improved magnetic regulation of delivery profiles from ferrogels,” Biomaterials 161, 179–189 (2018).
G. V. Kurlyandskaya, E. Fernandez, A. P. Safronov, A. V. Svalov, I. V. Beketov, A. B. Beitia, A. Garcia-Arribas, and F. A. Blyakhman, “Giant magnetoimpedance biosensor for ferrogel detection: Model system to evaluate properties of natural tissue,” Appl. Phys. Lett. 106, 193702 (2015).
N. A. Buznikov, A. P. Safronov, I. Orue, E. V. Golubeva, V. N. Lepalovskij, A. V. Svalov, A. A. Chlenova, and G. V. Kurlyandskaya, “Modelling of magnetoimpedance response of thin film sensitive element in the presence of ferrogel: Next step toward development of biosensor for in-tissue embedded magnetic nanoparticles detection,” Biosens. Bioelectron. 117, 366–372 (2018).
F. A. Blyakhman, A. P. Safronov, A. Yu. Zubarev, T. F. Shklyar, O. G. Makeyev, E. B. Makarova, V. V. Melekhin, A. Larrañaga, and G. V. Kurlyandskaya, “Polyacrylamide ferrogels with embedded maghemite nanoparticles for biomedical engineering,” Results Phys. 6, 3624–3633 (2017).
F. A. Blyakhman, A. P. Safronov, O. G. Makeyev, V. V. Melekhin, T. F. Shklyar, A. Yu. Zubarev, E. B. Makarova, D. A. Sichkar, M. A. Rusinova, S. Yu. Sokolov, and G. V. Kurlyandskaya, “Effect of the polyacrylamide ferrogel elasticity on the cell adhesiveness to magnetic composite,” J. Mech. Medicine Biology 18, 1850060 (2018).
D. E. Discher, P. Janmey, and Y. L. Wang, “Tissue cells feel and respond to the stiffness of their substrate,” Science 310, 1139–1143 (2005).
A. Cretu, P. Castagnino, and R. Assoian, “Studying the effects of matrix stiffness on cellular function using acrylamide-based hydrogels,” J. Visualized Exp., No. 42. e2089 (2010).
A. Trappmann, J. E. Gautrot, J. T. Connelly, D. G. T. Strange, Y. Li, M. L. Oyen, M. A. C. Cohen Stuart, H. Boehm, B. Li, V. Vogel, J. P. Spatz, F. M. Watt, and W. T. S. Huck, “Extracellular-matrix tethering regulates stem-cell fate,” Nat. Mater. 11, 642–649 (2012).
C. A. Mullen, T. J. Vaughan, K. L. Billiar, and L. M. McNamara, “The effect of substrate stiffness, thickness, and cross-linking density on osteogenic cell behavior,” Biophys. J. 108, 1604–1612 (2015).
F. A. Blyakhman, E. B. Makarova, F. A. Fadeyev, D. V. Lugovets, A. P. Safronov, P. A. Shabadrov, T. F. Shklyar, G. Yu. Melnikov, I. Orue, and G. V. Kurlyandskaya, “The contribution of magnetic nanoparticles to ferrogel biophysical properties,” Nanomaterials 9 (2), article No. 232 (2019).
J. H. Grossman and S. E. McNeil, “Nanotechnology in cancer medicine,” Phys. Today 65, 38–42 (2012).
Yu. A. Kotov, “Electric explosion of wires as a method for preparation of nanopowders,” J. Nanopart. Res. 5, 539–550 (2003).
A. P. Safronov, I. V. Beketov, S. V. Komogortsev, G. V. Kurlyandskaya, A. I. Medvedev, D. V. Leiman, A. Larranaga, and S. M. Bhagat, “Spherical magnetic nanoparticles fabricated by laser target evaporation,” AIP Adv. 3, 052135 (2013).
F. A. Blyakhman, L. Y. Iskakova, M. T. Lopez-Lopez, and A. Y. Zubarev, “To the theory of mechano-magnetic effects in ferrogels,” J. Magn. Magn. Mater. 478, 211–215 (2019).
G. Glavan, P. Salamon, I. A. Belyaeva, M. Shamonin, and I. Drevenšek-Olenik, “Tunable surface roughness and wettability of a soft magnetoactive elastomer,” J. Appl. Polym. Sci. 135, 46221 (2018).
V. V. Sorokin, B. O. Sokolov, G. V. Stepanov, and E. Y. Kramarenko, “Controllable hydrophobicity of magnetoactive elastomer coatings,” J. Magn. Magn. Mater. 459, 268–271 (2018).
This study was supported by the Russian Science Foundation, grant no. 18-19-00090.
Translated by D. Safin
About this article
Cite this article
Blyakhman, F.A., Makarova, E.B., Shabadrov, P.A. et al. Magnetic Nanoparticles as a Strong Contributor to the Biocompatibility of Ferrogels. Phys. Metals Metallogr. 121, 299–304 (2020). https://doi.org/10.1134/S0031918X2004002X
- magnetic nanoparticles
- tissue engineering