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Novel Glycyrrhetinic Acid Derivative Soloxolone Methyl Inhibits the Inflammatory Response and Tumor Growth in vivo

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Abstract

Due to wide spreading of inflammatory disease and imperfection of available anti-inflammatory drugs, mainly associated with their serious side effects, searching for new anti-inflammatory agents is a pressing problem. Natural triterpenoids and their synthetic analogs are a promising source of new drugs. In this study, we have investigated the anti-inflammatory and antitumor effects in vivo of the glycyrrhetinic acid derivative soloxolone methyl (SM), or methyl 2-cyano-3,12-dioxo-18βH-olean-9(11),1(2)-dien-30-oate. SM was shown to efficiently suppress the development of edema in a mouse model of carrageenan- or histamine- induced acute inflammation. SM also inhibited the tumor growth and reduced the tumor cell count in the ascitic fluid in mice bearing Krebs-2 carcinoma, the development of which is accompanied by an inflammatory process in the surrounding tissues.

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Abbreviations

DMSO:

dimethyl sulfoxide

LPS:

lipopolysaccharide

NSAID:

nonsteroidal anti-inflammatory drug

SM:

soloxolone methyl

PBS:

phosphate-buffered saline

COX-2:

cyclooxygenase 2

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Authors and Affiliations

  1. Institute of Chemical Biology and Fundamental Medicine, Siberian Branch, Russian Academy of Sciences, Novosibirsk, 630090, Russia

    A. V. Markov, A. V. Sen’kova, M. A. Zenkova & E. B. Logashenko

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  1. A. V. Markov
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  2. A. V. Sen’kova
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  3. M. A. Zenkova
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  4. E. B. Logashenko
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Correspondence to A. V. Markov.

Additional information

Original Russian Text © A.V. Markov, A.V. Sen’kova, M.A. Zenkova, E.B. Logashenko, 2018, published in Molekulyarnaya Biologiya, 2018, Vol. 52, No. 2, pp. 306–313.

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Markov, A.V., Sen’kova, A.V., Zenkova, M.A. et al. Novel Glycyrrhetinic Acid Derivative Soloxolone Methyl Inhibits the Inflammatory Response and Tumor Growth in vivo. Mol Biol 52, 262–268 (2018). https://doi.org/10.1134/S0026893318020073

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  • DOI: https://doi.org/10.1134/S0026893318020073

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