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Role of the Nucleolus in Rearrangements of the IGH Locus

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Abstract

The review summarizes the results from a series of studies focusing on the role that the nucleolus plays in maturation of the IGH locus and the choice of its partner genes in leukemia-associated translocations. The role of nuclear compartmentalization and nuclear localization of translocated oncogenes in ectopic activation of their transcription is discussed.

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Authors and Affiliations

  1. Institute of Gene Biology, Russian Academy of Sciences, Moscow, 119334, Russia

    O. V. Iarovaia, E. S. Ioudinkova & S. V. Razin

  2. LIA1066 “Laboratoire franco-russe de recherche en oncologie”, Villejuif, France

    O. V. Iarovaia, E. S. Ioudinkova, S. V. Razin & Y. S. Vassetzky

  3. Biological Faculty, Moscow State University, Moscow, 119991, Russia

    S. V. Razin & Y. S. Vassetzky

  4. CNRS UMR8126, Universite Paris Sud 11, Institut de Cancerologie Gustave Roussy, Villejuif, F-94805, France

    O. V. Iarovaia, E. S. Ioudinkova & Y. S. Vassetzky

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  1. O. V. Iarovaia
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  2. E. S. Ioudinkova
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  3. S. V. Razin
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  4. Y. S. Vassetzky
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Correspondence to O. V. Iarovaia.

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Original Russian Text © O.V. Iarovaia, E.S. Ioudinkova, S.V. Razin, Y.S. Vassetzky, 2018, published in Molekulyarnaya Biologiya, 2018, Vol. 52, No. 2, pp. 210–219.

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Iarovaia, O.V., Ioudinkova, E.S., Razin, S.V. et al. Role of the Nucleolus in Rearrangements of the IGH Locus. Mol Biol 52, 182–189 (2018). https://doi.org/10.1134/S0026893317050211

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