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Molecular components of JAK/STAT signaling pathway and its interaction with transcription machinery

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Abstract

JAK/STAT is a conserved signaling pathway in higher eukaryotes that plays a critical role in different processes of ontogenesis. This article reviews the pathway structure at the molecular level, mainly in Drosophila as a model organism. The review is focused on the data concerning the relationship between this signaling pathway and transcription machinery of higher eukaryotes.

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Abbreviations

BRG1:

Brahma-related gene protein 1

CBP/p300:

CREB binding protein and p300

CNTFR:

ciliary neurotrophic factor receptor

DOME:

domeless receptor of the JAK/STAT pathway in drosophila

gp130:

glycoprotein 130, a cytokine receptor

HOP:

hopscotch Janus kinase in drosophila

IFN:

interferon

IL:

interleukin

JAK:

janus kinase

LIFR:

leukemia inhibitory factor receptor

NF-κB:

nuclear factor kappa-light-chain-enhancer of activated B cells

PIAS:

protein inhibitors of activated STATs

PTPs:

protein tyrosine phosphatases

SOCS:

supressors of cytokine signaling

STAT:

signal transducer and activator of transcription

TFIID:

transcription factor IID

Tyk-2:

tyrosine protein kinase-2

UPD:

unpaired ligand family involved in JAK/STAT activation in drosophila

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Authors and Affiliations

  1. Institute of Gene Biology, Russian Academy of Sciences, Moscow, 119334, Russia

    A. V. Shaposhnikov, I. F. Komar’kov, L. A. Lebedeva & Yu. V. Shidlovskii

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  1. A. V. Shaposhnikov
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  2. I. F. Komar’kov
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  3. L. A. Lebedeva
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  4. Yu. V. Shidlovskii
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Correspondence to A. V. Shaposhnikov.

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Original Russian Text © A.V. Shaposhnikov, I.F. Komar’kov, L.A. Lebedeva, Yu.V. Shidlovskii, 2013, published in Molekulyarnaya Biologiya, 2013, Vol. 47, No. 3, pp. 388–397.

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Shaposhnikov, A.V., Komar’kov, I.F., Lebedeva, L.A. et al. Molecular components of JAK/STAT signaling pathway and its interaction with transcription machinery. Mol Biol 47, 343–351 (2013). https://doi.org/10.1134/S0026893313030126

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