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Three New Metal-Organic Coordination Complexes: Crystal Structures and Anticancer Activity in Multiple Myeloma

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Abstract

Three new metal-organic coordination complexes, namely [Cu(4,4′-bipy)2(NCS)2]n (I), [Cu(HCOO)2(4,4′—bipy)] (II), and [Cu(2,2′-bipy)2]2(V6O17) (III) (4,4′-bipy and 2,2′-bipy = 4,4′-bipyridine and 2,2′-bipyridine, respectively) are successfully prepared by using two similar pyridine ligands with different orientations of N atoms under different reaction conditions (slow volatilization for I, solvothermal for II and III). Their structures and compositions are characterized by both single crystal X-ray diffraction and elemental analysis. Additionally, the newly synthesized compounds are evaluated to identify the molecular characteristics contributing to their cytotoxicity. They are tested against three human multiple myeloma cells (NCI-H929, MM1S, and MM1R) with the MTT assay.

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References

  1. R. P. Perez, T. C. Hamilton, R. F. Ozols, and R. C. Young. Cancer, 1993, 71, 1571.

    Article  CAS  PubMed  Google Scholar 

  2. E. Won and C. M. Giandomenico. Chem. Rev., 1999, 99, 2451.

    Article  CAS  Google Scholar 

  3. L. Rubbia-Brandt. Ann. Oncol., 2004, 15, 460.

    Article  CAS  PubMed  Google Scholar 

  4. D. Senthil Raja, E. Ramachandran, N. S. P. Bhuvanesh, and K. Natarajan. Eur. J. Med. Chem., 2013, 64, 148.

    Article  CAS  PubMed  Google Scholar 

  5. B. Cvek, V. Milacic, J. Taraba, and Q. P. Dou. J. Med. Chem., 2008, 51, 6256.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  6. C. J. Anderson and R. Ferdani. Cancer Biother. Radiopharm., 2009, 24, 379.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  7. M. T. Tarafder, K. T. Jin, K. A. Crouse, A. Ali, B. Yamin, and H. K. Fun. Polyhedron, 2002, 21, 2547.

    Article  CAS  Google Scholar 

  8. Y. Feng, H. Fan, Z. Zhong, H. Wang, and D. Qiu. Inorg. Chem., 2016, 55, 11987.

    Article  CAS  Google Scholar 

  9. Y. Feng, M. Li, H. Fan, Q. Huang, D. Qiu, and H. Shi. Dalton Trans., 2015, 44, 894.

    Article  CAS  Google Scholar 

  10. C. W. Duan, L. X. Hu, and J. L. Ma. J. Mater. Chem. A, 2018, 6, 6309.

    Article  CAS  Google Scholar 

  11. D. J. Collins and H. C. Zhou. J. Mater. Chem., 2007, 17, 3154.

    Article  CAS  Google Scholar 

  12. D. Feng, Z. Y. Gu, J. R. Li, H. L. Jiang, Z. Wei, and H. C. Zhou. Angew. Chemie-Int. Ed., 2012, 51, 10307.

    Article  CAS  Google Scholar 

  13. A. M. Spokoyny, D. Kim, A. Sumrein, and C. A. Mirkin. Chem. Soc. Rev. 2009, 38, 1218.

    Article  CAS  PubMed  Google Scholar 

  14. R. Koner and I. Goldberg. Acta Crystallogr. Sect. C, Cryst. Struct. Commun., 2009, 65, m185.

    Article  CAS  Google Scholar 

  15. J. W. Cui, X. B. Cui, H. H. Yu, J. Q. Xu, and S. H. Wang. Acta Crystallogr. Sect. E, Struct. Rep. Online, 2010, 66, m568.

    Article  CAS  Google Scholar 

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Authors and Affiliations

  1. Department of Hematology, Wuhan Fourth Hospital, Puai Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, P. R. China

    Y. -Y. Yang, J. -H. Yang & D. Wang

Authors
  1. Y. -Y. Yang
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  2. J. -H. Yang
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  3. D. Wang
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Correspondence to D. Wang.

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Text © The Author(s), 2019, published in Zhurnal Strukturnoi Khimii, 2019, Vol. 60, No. 5, pp. 871-877.

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Yang, Y.Y., Yang, J.H. & Wang, D. Three New Metal-Organic Coordination Complexes: Crystal Structures and Anticancer Activity in Multiple Myeloma. J Struct Chem 60, 838–844 (2019). https://doi.org/10.1134/S0022476619050184

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  • DOI: https://doi.org/10.1134/S0022476619050184

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