Abstract
Retzius neuron (RN) in the medicinal leech is known to function as a typical neurosecretory cell. This study addresses the relationship between its two functions, neural and paracrine. It was shown that synaptic activation of RN at 710-Hz frequencies causes the neurophysiological process of habituation. Experiments conducted in calcium-free solution and in that containing nimodipine and colchicine (which block somatic exocytosis of serotonin under these experimental conditions) demonstrate alterations in the electrophysiological characteristics of RN: the rate of spontaneous impulse activity (IA), action potential (AP) amplitude, and synaptic stimulation threshold. Under these conditions, RN generates AP to every stimulus even at frequencies of 7 to 10 Hz. Thus, while somatic exocytosis of serotonin is blocked, habituation does not develop. It is suggested that habituation of RN to high-frequency synaptic stimulation is mediated by the concurrent effects of two factors — stimulatory (via synaptic activation) and inhibitory (via autoinhibition).
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Abbreviations
- RN:
-
Retzius neuron
- AP:
-
action potential
- IA:
-
impulse activity
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Original Russian Text © S.S. Sergeeva, A.A. Laktionova, N.Yu. Fomina, 2018, published in Zhurnal Evolyutsionnoi Biokhimii i Fiziologii, 2018, Vol. 54, No. 4, pp. 292–297.
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Sergeeva, S.S., Laktionova, A.A. & Fomina, N.Y. Effects of Nimodipine, Calcium-Free Medium and Colchicine on Electrogenesis of Neurosecretory Retzius Cells in the Leech Hirudo medicinalis. J Evol Biochem Phys 54, 332–337 (2018). https://doi.org/10.1134/S0022093018040105
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DOI: https://doi.org/10.1134/S0022093018040105