Evolutionary Aspects of Cardioprotection

  • I. V. Shemarova
  • V. P. Nesterov
  • S. M. Korotkov
  • Yu. A. Sylkin


The review addresses the mechanisms of adaptation of the myocardium and cells of the cardiovascular system to hypoxia and ischemia as well as biochemical mechanisms of cardioprotection in animals of different phylogenetic levels. A special focus is placed on general adaptive strategies developed by evolutionarily distant animals in response to hypoxia and ischemia and on preconditioning and myocardial hibernation phenomena.


cardioprotection hypoxia ischemia preconditioning hibernation 


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Copyright information

© Pleiades Publishing, Ltd. 2018

Authors and Affiliations

  • I. V. Shemarova
    • 1
  • V. P. Nesterov
    • 1
  • S. M. Korotkov
    • 1
  • Yu. A. Sylkin
    • 2
  1. 1.Sechenov Institute of Evolutionary Physiology and BiochemistryRussian Academy of SciencesSt. PetersburgRussia
  2. 2.T.I. Vyazemsky Karadag Scientific StationNature Reserve of the Russian Academy of SciencesSt. PetersburgRussia

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