Structure and Dynamics of Ternary Complexes of Cucurbituril with Spin-Labeled Indicators and Biologically Active Analytes
- 20 Downloads
Ternary host–guest complexes have been first obtained from cucurbituril CB as a host molecule and two guest molecules: nitroxyl probes of different structures and biologically important amino acids (AA) and aromatic compounds. To characterize the binding of the guests, parameters of the polarity of the environment and the rotational mobility of the spin probes have been used. These parameters have been shown to depend on the nature of the analytes. For the ternary complexes, in addition to the usual triplet ESR spectra from nitroxyl probes (S3), supramolecular ensembles consisting of three equivalent ternary complexes (“triads”) have been found, whose ESR spectra have a seven-component hyperfine structure (S7) due to delocalization of the unpaired electron over three nitrogen nuclei. The relative intensity of the S7 spectra increases with increasing NaCl concentration in the solution, and also depends significantly on the nature of the analyte and the spin probe. Quantum chemical calculations have shown that (1) to determine the stability of the complexes, it is necessary to allow for the van der Waals interaction, and (2) the complexes involving the zwitterionic form of AA are much more stable than those with the neutral form of AA.
Keywordscucurbituril CB host–guest complexes ternary complexes nitroxyl radicals chemosensors ESR spectra amino acids calculations by the PM3 and PM6 methods
Unable to display preview. Download preview PDF.
- 2.Isaacs, L., Chem. Commun., 2009, p.619.Google Scholar
- 4.Wagner, B.D., Stojanovic, N., Day, A.I., and Blanch, R.J., J. Phys. Chem. B, vol. 2003, p. 10741.Google Scholar
- 14.Mezzina, E., Cruciani, F., Pedulli, G.F., and Lucarini, M., Chem.-Eur. J., 2007, p. 7223.Google Scholar
- 19.Rozantsev, E.G., Svobodnye iminoksil’nye radikaly (Free Iminoxyl Radicals), Moscow: Khimiya, 1970.Google Scholar
- 20.Spin Labeling: Theory and Applications, Berliner, L, Ed., New York: Academic, 1976.Google Scholar
- 23.Jayarai, N., Porel, M., Ottaviani, F., Maddipatla, M.V.S.N., Modelli, A., Da Silva, J.P., Bohogala, B.R., Captain, B., Jockusch, S., Turro, N.J., and Ramamurthy, V., Langmuir, 2009, vol. 25, no. 24, p. 13632.Google Scholar
- 24a.(b)Stewart, J.J.P., MOPAC 2012, Version 1.038W, Colorado Springs, CO: Stewart Computational Chemistry, 2012. http://OpenMopac.net.Google Scholar
- 25.Biochemistry, Berg, J.M., Tymoczko, J.L. and Stryer, L., New York: W. H. Freeman and Company, 2006, 6th ed., ch. 02.Google Scholar