Abstract
The electrospray method was used for the first time to prepare polymeric capsules from bioresorbable dl-lactide and glycolide copolymer loaded with biological molecules from the cell secretome and, in particular, human interferon-α-2b (IFNα-2b). The obtained nearly spherical submicron capsules were studied by scanning electron and confocal laser microscopy. The capsules retain the structural integrity and the cytotoxic activity of IFNα-2b towards tumor cells. The electrospray method is distinguished by high adaptability and environmental safety and is suitable for manufacture of a broad range of materials with different composition and morphology promising for the targeted delivery of drugs and biological molecules.
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ACKNOWLEDGMENTS
The authors are grateful to the employees of the Laboratory of the Physicochemical Methods of Analysis of the Tomsk State University for NMR and gas chromatography studies.
The work was supported by the Ministry of Education and Science of the Russian Federation, contract No. 14.575.21.0164 of September 26, 2017 (unique identifier RFMEFI57517X0164) as a part of the Federal Target Program “Research and Development in the Priority Areas of the Science and Technology Sector of Russia for 2014–2020.”
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Translated by Z. Svitanko
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Khlusov, I.A., Kibler, E.V., Kudryavtseva, V.L. et al. Electrospray Preparation of Biocompatible Lactide–Glycolide Copolymer Capsules with Incorporation of Interferon. Dokl Chem 484, 74–78 (2019). https://doi.org/10.1134/S0012500819020095
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DOI: https://doi.org/10.1134/S0012500819020095