Abstract
The relationship between the development of skeletal muscle fatigue of a specific type in male Wistar rats and morphofunctional alterations in the myocardium in the posttraumatic stress disorder (PTSD) model has been investigated for the first time. The aggravation of oxidative stress in the cardiomyocytes and the related transformation of the cell structural components and the depletion of energy reserves in PTSD has been identified as one of the main factors that accelerate the onset of musculoskeletal fatigue.
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REFERENCES
Edmondson, D. and von Känel, R., Lancet Psychiatry, 2017, vol. 4, pp. 320–329.
Pitman, R.K., Rasmusson, A.M., Koenen, K.C., et al., Nat. Rev. Neurosci., 2012, vol. 13, pp. 769–787.
Koenen, K.C., Sumner, J.A., Gilsanz, P., et al., Psychol. Med., 2017, vol. 47, pp. 209–225.
Oddone, A.E., Dennis, P.A., Calhoun, P.S., et al., Psychol. Trauma, 2015, vol. 7, pp. 229–233.
Ebner, K. and Singewald, N., Curr. Opin. Behav. Sci., 2017, vol. 14, pp. 54–64.
Zoladz, P.R., Park, C.R., Fleshner, M., et al., Physiol. Behav., 2015, vol. 147, pp. 183–192.
Sapolsky, R.M., Romero, L.M., and Munck, A.U., Endocr. Rev., 2000, vol. 21, pp. 55–89.
Lazuko, S.S., Kuzhel, O.P., Belyaeva, L.E., Manukhina, E.B., Fred Downey, H., Tseilikman, O.B., Komelkova, M.V., and Tseilikman, V.E., Cell. Mol. Neurobiol., 2018, vol. 38, pp. 209–217.
Klinicheskaya laboratornaya analitika, vol. 2: Chastnye analiticheskie tekhnologii v klinicheskoi laboratorii (Clinical Laboratory Analytics, vol. 2: Specific Analytical Technologies in Clinical Laboratory), Men’shi-kov, V.V., Ed., Moscow: Labinform-RAMLD, 1999.
Volchegorskii, I.A., Dolgushin, I.I., Kolesnikov, O.L., and Tseilikman, V.E., Eksperimental’noe modelirovanie i laboratornaya otsenka adaptatsionnykh reaktsii organizma (Experimental Simulation and Laboratory Estimation of Adaptive Responses of the Body), Che-lyabinsk: Chelyab. Gos. Ped. Univ., 2000.
Dubinina, E.E., Burmistrov, S.O., Khodov, D.A., and Porotov, I.G., Vopr. Med. Khimii, 1995, vol. 41, no. 1, pp. 24–26.
Chandramouli, C., Varma, U., Stevens, E.M., et al., Clin. Exp. Pharmacol. Physiol., 2015, vol. 42, pp. 415–425.
ACKNOWLEDGMENTS
This study was performed in the framework of the basic part of State Contract no. 17.7255.2017/8.9 with the Ministry of Education and Science of the Russian Federation and the State Contract with the Institute of Immunology and Physiology of the Ural Branch of the Russian Academy of Sciences (topic no. AAAA-A18-118020590108-7).
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Statement on the welfare of animals. All experimental procedures were approved by the local ethical committee and implemented according to the EC Declaration on handling laboratory animals (2010).
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Translated by S. Semenova
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Kondashevskaya, M.V., Tseylikman, V.E., Komelkova, M.V. et al. Physical Fatigue and Morphofunctional State of the Myocardium in Experimental Chronic Stress. Dokl Biol Sci 485, 30–32 (2019). https://doi.org/10.1134/S0012496619020042
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DOI: https://doi.org/10.1134/S0012496619020042