Application of EPR Spectroscopy in the Study of Iron Metabolism in Parkinson’s Disease

Abstract—A brief review of the authors’ work on the use of low-temperature EPR spectroscopy in blood tests of patients with Parkinson’s disease and tissues of rat organs taken in experiments that simulate the early stages of parkinsonism is presented. An analysis of the obtained and published data suggests that the process of hemoglobin degradation can be included in the list of fundamental characteristics of the pathogenesis of Parkinson’s disease.

This is a preview of subscription content, log in to check access.

REFERENCES

  1. 1

    H. Jiang, J. Wang, J. Rogers, and J. Xie, Mol. Neurobiol. 54, 3078 (2017). .https://doi.org/10.1007/s12035-016-9879-1

    Article  Google Scholar 

  2. 2

    S. R. Danielson and J. K. Andersen, Free Radic. Biol. Med. 44, 1787 (2008).

    Article  Google Scholar 

  3. 3

    O. Hwang, Exp. Neurobiol. 22, 11 (2013).

    Article  Google Scholar 

  4. 4

    J. Blesa, I. Trigo-Damas, and A. Quiroga-Varela, Front Neuroanat. 9, 91 (2015).

    Google Scholar 

  5. 5

    G. H. Kim, J. E. Kim, S. J. Rhie, et al., Exp. Neurobiol. 24 (4), 325 (2015).

    Article  Google Scholar 

  6. 6

    J. Freed and L. Chakrabarti, NPJ Parkinson’s Disease 2, 16021 (2016) .https://doi.org/10.1038/npjparkd.2016.21

    Article  Google Scholar 

  7. 7

    R. D. Abbott, G. W. Ross, C. M. Tanner, et al., Neurobiol. Aging 33, 914 (2012).

    Article  Google Scholar 

  8. 8

    M. G. Makletsova, G. T. Rikhireva, S. L. Stvolinskii, et al., Byull. Eksp. Biol. Med. 152 (9), 330 (2011).

    Google Scholar 

  9. 9

    M. G. Makletsova, G. T. Rikhireva, V. V. Poleshchuk, et al., Biomed. Khim. 62 (2), 193 (2016).

    Article  Google Scholar 

  10. 10

    B. L. Kurlyandskii and V. A. Filov, General Toxicology (Moscow, 2002) [in Russian].

    Google Scholar 

  11. 11

    L. Mohorovic, F. M. Lavezzi, S. Stifter, et al., Adv. Biosci. Biotechnol. 5 (1), 2014).

  12. 12

    R. Savica, B. R. Grossardt, J. M. Carlin, et al., Neurology 73, 1381 (2009).

    Article  Google Scholar 

  13. 13

    Q. Deng, X. Zhon, J. Chen, et al., Brain Res. 1655, 145 (2017).

    Article  Google Scholar 

  14. 14

    M. G. Makletsova, T. N. Fedorova, V. V. Poleshchuk, and G. T. Rikhireva, Biophysics (Moscow) 62 (2), 247 (2017).

    Article  Google Scholar 

  15. 15

    A. Moghe, S. Ghare, B. Lamoreau, et al., Toxicol. Sci. 143 (2), 242 (2015).

    Article  Google Scholar 

  16. 16

    A. V. Kozlov, V. I. Serpienko, Yu. A. Vladimirov et al., Byull. Eksp. Biol. Med. 98, 668 (1984).

    Google Scholar 

  17. 17

    M. G. Makletsova, G. T. Rikhireva, V. V. Poleshchuk, and S. N. Illarioshkin, Biophysics (Moscow) 62 (6), 994 (2017).

    Article  Google Scholar 

  18. 18

    S. N. Illarioshkin, L. G. Khaspekov, and I. A. Gri-vevennikov, Parkinson’s Disease Modeling Using Pluripotent Stem Cells (Moscow, 2016) [in Russian].

    Google Scholar 

  19. 19

    A. V. Nepoklonov, I. G. Kapitsa, E. A. Ivanova, et al., Neirofarmakologiya 75 (11), 3 (2012).

    Google Scholar 

  20. 20

    M. G. Makletsova, G. T. Rikhireva, K. V. Gryakalov, et al., Asimmetriya 12 (4), 336 (2018).

    Google Scholar 

  21. 21

    M. K. Pulatova, G. T. Rikhireva, and Z. V. Kuropteva, Electron Paramagnetic Resonance in Molecular Radiobiology (Energoatomizdat, Moscow, 1989) [in Russian].

    Google Scholar 

  22. 22

    M. Moccia, M. Picillo, R. Erro, et al., Eur. J. Neurol. 22, 954 (2015).

    Article  Google Scholar 

  23. 23

    Macias-Garcia, C. Mendez-Del Barrio, S. Jesus, et al., Parkinsonism Relat. Disord. 63, 213 (2019). .https://doi.org/10.1016/j.parkreldis.2019.01.012

    Article  Google Scholar 

  24. 24

    M. F. McCarty, Med. Hypotheses 81, 607 (2013).

    Article  Google Scholar 

Download references

Funding

This work was performed as part of the State Assignment of the Ministry of Education and Science of Russia (theme 0082-2014-0001, no. AAAA-A17-117040610310-6).

Author information

Affiliations

Authors

Corresponding authors

Correspondence to G. T. Rikhireva or M. G. Makletsova.

Ethics declarations

Conflict of interests

The authors declare that they have no conflict of interest.

Statement on the welfare of animals

All applicable international, national, and/or institutional guidelines for the care and use of animals were followed.

Additional information

Translated by G. Levit

Abbreviations: EPR, electron paramagnetic resonance; MetHb, methemoglobin; МРТР, 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine.

Rights and permissions

Reprints and Permissions

About this article

Verify currency and authenticity via CrossMark

Cite this article

Rikhireva, G.T., Makletsova, M.G. Application of EPR Spectroscopy in the Study of Iron Metabolism in Parkinson’s Disease. BIOPHYSICS 65, 327–330 (2020). https://doi.org/10.1134/S0006350920020190

Download citation

  • Keywords: Parkinson’s disease
  • EPR spectroscopy
  • iron metabolism
  • hemoglobin