Application of EPR Spectroscopy in the Study of Iron Metabolism in Parkinson’s Disease

Abstract—A brief review of the authors’ work on the use of low-temperature EPR spectroscopy in blood tests of patients with Parkinson’s disease and tissues of rat organs taken in experiments that simulate the early stages of parkinsonism is presented. An analysis of the obtained and published data suggests that the process of hemoglobin degradation can be included in the list of fundamental characteristics of the pathogenesis of Parkinson’s disease.

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This work was performed as part of the State Assignment of the Ministry of Education and Science of Russia (theme 0082-2014-0001, no. AAAA-A17-117040610310-6).

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Corresponding authors

Correspondence to G. T. Rikhireva or M. G. Makletsova.

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The authors declare that they have no conflict of interest.

Statement on the welfare of animals

All applicable international, national, and/or institutional guidelines for the care and use of animals were followed.

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Translated by G. Levit

Abbreviations: EPR, electron paramagnetic resonance; MetHb, methemoglobin; МРТР, 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine.

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Rikhireva, G.T., Makletsova, M.G. Application of EPR Spectroscopy in the Study of Iron Metabolism in Parkinson’s Disease. BIOPHYSICS 65, 327–330 (2020).

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  • Keywords: Parkinson’s disease
  • EPR spectroscopy
  • iron metabolism
  • hemoglobin