Abstract
The effect of taurine on membrane-associated processes was studied in rat erythrocytes and peritoneal mast cells. EPR with a spin probe 5-DS revealed a significant decrease in the order parameter S of membrane phospholipid acyl chains in vitro after incubation of erythrocytes with taurine (10 mM, 1 h). Increased susceptibility of the erythrocyte membrane to peroxide-induced lysis was also observed. These effects suggested decreased membrane microviscosity resulting from less dense packing of the phospholipids. The differential effects of taurine on stimulated Ca-dependent functional activity of peritoneal mast cells (histamine liberation) upon different ways of administration (oral, intraperitoneal, or intramuscular) suggest an indirect and complex mechanism of taurine action in the organism.
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Original Russian Text © M.Ya. Akhalaya, E.A. Kushnareva, E.Yu. Parshina, A.G. Platonov, E.E. Graevskaya, 2012, published in Biofizika, 2012, Vol. 57, No. 4, pp. 641–648
The experimental data contained herein fully correspond to the original publication but the text has been substantially revised for the English version. A.G.
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Akhalaya, M.Y., Kushnareva, E.A., Parshina, E.Y. et al. Membrane-modifying effect of taurine. BIOPHYSICS 57, 485–490 (2012). https://doi.org/10.1134/S000635091204001X
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DOI: https://doi.org/10.1134/S000635091204001X