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RNA (C5-cytosine) Methyltransferases

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Abstract

The review summarizes the data on pro- and eukaryotic RNA (C5-cytosine) methyltransferases. The structure, intracellular location, RNA targets, and catalytic mechanisms of these enzymes, as well as the functional role of methylated cytosine residues in RNA are presented. The functions of RNA (C5-cytosine) methyltransferases unassociated with their methylation activity are discussed. Special attention is given to the similarities and differences in the structures and mechanisms of action of RNA and DNA methyltransferases. The data on the association of mutations in the RNA (C5-cytosine) methyltransferases genes and human diseases are presented.

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Abbreviations

m5C:

5-methylcytosine

RNA-C5-methyltransferase:

RNA (C5-cytosine) methyltransferase

SAM:

S-adenosyl-L-methionine

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Funding

Funding. The work was supported by the Russian Science Foundation (project 17-75-30027) and Russian Foundation for Basic Research (project 17-00-00366).

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  1. These authors contributed equally to this work.

Authors and Affiliations

  1. Lomonosov Moscow State University, Institute of Functional Genomics, 119234, Moscow, Russia

    S. A. Kuznetsova & P. V. Sergiev

  2. Lomonosov Moscow State University, Faculty of Chemistry, 119991, Moscow, Russia

    K. S. Petrukov, F. I. Pletnev, P. V. Sergiev & O. A. Dontsova

  3. Skolkovo Institute of Science and Technology, 121205, Skolkovo, Moscow Region, Russia

    F. I. Pletnev, P. V. Sergiev & O. A. Dontsova

  4. Institute of Bioorganic Chemistry, 117997, Moscow, Russia

    F. I. Pletnev & O. A. Dontsova

  5. Petrov National Medical Research Center of Oncology, 197758, St. Petersburg, Russia

    P. V. Sergiev

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  1. S. A. Kuznetsova
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Russian Text © The Author(s), 2019, published in Biokhimiya, 2019, Vol. 84, No. 8, pp. 1076–1098.

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Kuznetsova, S.A., Petrukov, K.S., Pletnev, F.I. et al. RNA (C5-cytosine) Methyltransferases. Biochemistry Moscow 84, 851–869 (2019). https://doi.org/10.1134/S0006297919080029

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