Immunotherapeutic Approaches for the Treatment of Colorectal Cancer


Colorectal cancer (CRC) originating from the cells of the colon or rectum has a high mortality rate worldwide. Numerous attempts have been made to raise the overall survival rates of CRC patients. It is well-known that the development of malignant neoplasms is accompanied by suppression of the immune system, which is likely the cause for the failure of standard treatment methods. Immune response has long been an issue of great interest in cancer therapy and anti-tumor immunity that consider the development of immunotherapeutic antitumor methods resulting in the immune system activation as an important issue. This review discusses main immunotherapeutic approaches available for the CRC treatment.



adoptive cell immunotherapy

CAR T cell:

T cell with chimeric antigen receptor


carcinoembryonic antigen


colorectal cancer


dendritic cell


immune checkpoint inhibitor


high-avidity T-cell receptor


tumor-infiltrating lymphocyte


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Correspondence to E. V. Abakushina.

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Russian Text © The Author(s), 2019, published in Biokhimiya, 2019, Vol. 84, No. 7, pp. 923–933.

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Abakushina, E.V., Gelm, Y.V., Pasova, I.A. et al. Immunotherapeutic Approaches for the Treatment of Colorectal Cancer. Biochemistry Moscow 84, 720–728 (2019).

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  • colorectal cancer (CRC)
  • immunotherapy
  • checkpoint inhibition
  • programmed death 1 (PD-1)
  • adoptive cell immunotherapy