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Biochemistry (Moscow)

, Volume 83, Issue 4, pp 402–410 | Cite as

Effect of Environmental Factors on Nuclear Organization and Transformation of Human B Lymphocytes

  • F. B. Sall
  • D. Germini
  • A. P. Kovina
  • V. Ribrag
  • J. Wiels
  • A. O. Toure
  • O. V. Iarovaia
  • M. Lipinski
  • Y. Vassetzky
Review

Abstract

Chromosomal translocations have long been known for their association with malignant transformation, particularly in hematopoietic disorders such as B-cell lymphomas. In addition to the physiological process of maturation, which creates double strand breaks in immunoglobulin gene loci, environmental factors including the Epstein–Barr and human immunodeficiency viruses, malaria-causing parasites (Plasmodium falciparum), and plant components (Euphorbia tirucalli latex) can trigger a reorganization of the nuclear architecture and DNA damage that together will facilitate the occurrence of deleterious chromosomal rearrangements.

Keywords

Burkitt lymphoma EBV HIV Plasmodium falciparum Euphorbia tirucalli oncogenesis nuclear organization 

Abbreviations

AICDA

activation-induced cytosine deaminase

BL

Burkitt lymphoma

CSR

class switch recombination

DSBs

DNA double strand breaks

EBV

Epstein–Barr virus

HIV

human immunodeficiency virus

NHEJ

non-homologous end joining

RAG1(2)

recombination activating gene 1(2)

ROS

reactive oxygen species

SHM

somatic hypermutation

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Copyright information

© Pleiades Publishing, Ltd. 2018

Authors and Affiliations

  • F. B. Sall
    • 1
    • 2
    • 3
  • D. Germini
    • 1
    • 2
  • A. P. Kovina
    • 1
    • 2
    • 4
  • V. Ribrag
    • 5
    • 6
  • J. Wiels
    • 1
    • 2
  • A. O. Toure
    • 3
  • O. V. Iarovaia
    • 2
    • 4
  • M. Lipinski
    • 1
    • 2
  • Y. Vassetzky
    • 1
    • 2
    • 7
  1. 1.UMR8126, Université Paris-Sud, CNRSInstitut de Cancérologie Gustave RoussyVillejuifFrance
  2. 2.LIA1066 “Laboratoire Franco–Russe de Recherche en Oncologie”VillejuifFrance
  3. 3.Laboratoire d’Hématologie Centre Hospitalier Universitaire Aristide Le DantecUniversité Cheikh Anta DiopDakarSénégal
  4. 4.Institute of Gene BiologyRussian Academy of SciencesMoscowRussia
  5. 5.Institut Gustave RoussyVillejuifFrance
  6. 6.Institut National de la Santé et de la Recherche Médicale (INSERM) Unité (U) 1009, Université Paris SudInstitut Gustave RoussyVillejuifFrance
  7. 7.Koltzov Institute of Developmental BiologyRussian Academy of SciencesMoscowRussia

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