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The Role of Chromosome–Nuclear Envelope Attachments in 3D Genome Organization

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Abstract

Chromosomes are intricately folded and packaged in the cell nucleus and interact with the nuclear envelope. This complex nuclear architecture has a profound effect on how the genome works and how the cells function. The main goal of review is to highlight recent studies on the effect of chromosome–nuclear envelope interactions on chromatin folding and function in the nucleus. The data obtained suggest that chromosome–nuclear envelope attachments are important for the organization of nuclear architecture in various organisms. A combination of experimental cell biology methods with computational modeling offers a unique opportunity to explore the fundamental relationships between different aspects of 3D genome organization in greater details. This powerful interdisciplinary approach could reveal how the organization and function of the genome in the nuclear space is affected by the chromosome–nuclear envelope attachments and will enable the development of novel approaches to regulate gene expression.

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Abbreviations

Chr:

chromosome

DamID:

DNA adenine methyltransferase identification

FISH:

fluorescence in situ hybridization

Hi-C:

chromosome conformation capture

LAD:

lamina-associated domain

NE:

nuclear envelope

TAD:

topologically associated domain

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Authors and Affiliations

  1. Virginia Polytechnic Institute and State University, Fralin Life Science Institute, Department of Entomology, Blacksburg, VA, 24061, USA

    I. V. Sharakhov

  2. Tomsk State University, Laboratory of Ecology, Genetics and Environmental Protection, Tomsk, Russia

    I. V. Sharakhov, S. M. Bondarenko & G. N. Artemov

  3. Virginia Polytechnic Institute and State University, Department of Physics, Blacksburg, VA, 24060, USA

    A. V. Onufriev

  4. Virginia Polytechnic Institute and State University, Department of Computer Science, Blacksburg, VA, 24061, USA

    A. V. Onufriev

Authors
  1. I. V. Sharakhov
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  2. S. M. Bondarenko
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  3. G. N. Artemov
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  4. A. V. Onufriev
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Correspondence to I. V. Sharakhov.

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Sharakhov, I.V., Bondarenko, S.M., Artemov, G.N. et al. The Role of Chromosome–Nuclear Envelope Attachments in 3D Genome Organization. Biochemistry Moscow 83, 350–358 (2018). https://doi.org/10.1134/S0006297918040065

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  • DOI: https://doi.org/10.1134/S0006297918040065

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