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Biotechnological Aspects of the Enzymatic Preparation of Bioactive Chitooligosaccharides (Review)

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Abstract

The review describes recent technologies for the enzymatic preparation of chitooligosaccharides with chitosanases. Features of the microbial synthesis of chitosanases and approaches to the implementation of their biotechnological production are also highlighted. Tendencies in the development of methods and technologies for the targeted preparation of chitosan oligomers with the use of bioreactors and immobilized enzymes are considered.

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Funding

The work was partially financially supported by the Russian Science Foundation (project no. 16-14-00046).

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Authors and Affiliations

  1. Ufa Institute of Biology, Ufa Federal Research Center, Russian Academy of Sciences, 450054, Ufa, Russia

    G. E. Aktuganov & A. I. Melentiev

  2. Institute of Bioengineering, Fundamentals of Biotechnology Federal Research Center, Russian Academy of Sciences, 119071, Moscow, Russia

    V. P. Varlamov

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  1. G. E. Aktuganov
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  2. A. I. Melentiev
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  3. V. P. Varlamov
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Correspondence to G. E. Aktuganov.

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Translated by G. Levit

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Aktuganov, G.E., Melentiev, A.I. & Varlamov, V.P. Biotechnological Aspects of the Enzymatic Preparation of Bioactive Chitooligosaccharides (Review). Appl Biochem Microbiol 55, 323–343 (2019). https://doi.org/10.1134/S0003683819040021

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