Applied Biochemistry and Microbiology

, Volume 55, Issue 1, pp 25–31 | Cite as

Study of the Physicochemical and Biological Properties of a Protein–Peptide Complex Isolated from Cattle Ovarian Tissue

  • A. P. Ilyina
  • M. S. Krasnov
  • P. A. Elistratov
  • N. V. Yamskova
  • V. P. YamskovaEmail author
  • A. K. BuryakEmail author
  • I. A. YamskovEmail author


A protein–peptide complex isolated from cattle ovarian tissues was studied. It was shown that it contains polypeptides with molecular weights from 800 to 6000 Da and a protein of the mammalian albumin family with a molecular weight of 66 690 Da containing the 16-member N-terminal amino acid sequence DTHKSEIAHRFKDLGE. The use of a model of the roller organotypic cultivation of rat ovaries demonstrated that the effect of this protein–peptide complex at low total protein concentrations of 10–8–10–15 mg/mL contributes to increases in the viability and maturation of secondary follicles in rat ovarian tissues in vitro.


protein–peptide complex albumin bioregulator roller cultivation ovaries follicles 



The authors declare that they have no conflict of interest. This article does not contain any studies involving animals or human participants performed by any of the authors.


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© Pleiades Publishing, Inc. 2019

Authors and Affiliations

  1. 1.Nesmeyanov Institute of Organoelement Compounds, Russian Academy of SciencesMoscowRussia
  2. 2.Koltzov Institute of Developmental Biology, Russian Academy of SciencesMoscowRussia
  3. 3.Frumkin Institute of Physical Chemistry and Electrochemistry, Russian Academy of SciencesMoscowRussia

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