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Chitosan-Based Mucoadhesive Systems for the Inclusion of the Echinochrome Active Substance

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Abstract

Polyelectrolyte complexes (PECs) of chitosan (CH) with kappa/beta carrageenan (κ/β-K), a polysaccharide of red algae, were obtained in a soluble form and as films. Using porcine intestinal mucosa as a model, it was shown that single-layer films obtained from polysaccharides and a three-layer film containing their polyelectrolyte complex exhibited mucoadhesive properties. The mucoadhesive ability of the films depended on the polysaccharide type and changed after PEC formation. Comparative analysis of the ζ-potential values determined for the soluble form of polyelectrolyte complexes in an aqueous solution and in a mucin-containing solution confirmed the mucoadhesive properties of the PECs. It was found that the complexes retained their mucoadhesive properties upon the inclusion of echinochrome A in their soluble form. This made it possible to consider them noninvasive forms of drug delivery.

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Authors and Affiliations

  1. G.B. Elyakov Pacific Institute of Bioorganic Chemistry, Far Eastern Branch of the Russian Academy of Sciences, Vladivostok, 690022, Russia

    V. N. Davydova, A. V. Volod’ko, N. P. Mishchenko & I. M. Yermak

Authors
  1. V. N. Davydova
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  2. A. V. Volod’ko
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  3. N. P. Mishchenko
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  4. I. M. Yermak
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Correspondence to V. N. Davydova.

Additional information

Original Russian Text © V.N. Davydova, A.V. Volod’ko, N.P. Mishchenko, I.M. Yermak, 2018, published in Prikladnaya Biokhimiya i Mikrobiologiya, 2018, Vol. 54, No. 5, pp. 477–482.

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Davydova, V.N., Volod’ko, A.V., Mishchenko, N.P. et al. Chitosan-Based Mucoadhesive Systems for the Inclusion of the Echinochrome Active Substance. Appl Biochem Microbiol 54, 478–483 (2018). https://doi.org/10.1134/S0003683818050071

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  • DOI: https://doi.org/10.1134/S0003683818050071

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