Skip to main content
SpringerLink
Log in

Application of Chitosan in Veterinary Vaccine Production

  • Published:
Applied Biochemistry and Microbiology Aims and scope Submit manuscript

Abstract

Probability-based surveys of the application of chitosan succinate as an adjuvant added to the vaccine against animal necrobacteriosis have been performed. The addition of 3.7% chitosan succinate (MM 330 kDa) to the standard-dose vaccine formulation could contribute to improvement of the vaccine immunogenicity, as measured by the hemagglutination test (HA): 1 : 512 as compared to 1 : 128 in the control range. The use of 0.5-% chitosan succinate solution as a protective medium for drying in the production of a dried inactivated vaccine against infectious bovine rhinotracheitis could ensure the preservation of the biopreparation’s high immunogenic activity. Chitosan succinate was shown to have quite good solubility in water, allowing the possible use of saline solution to reconstitute the vaccine into the suspension for injection and to abandon expensive solvents.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Khitin i khitozan: Poluchenie, svoistva i primeneniya (Chitin and Chitosan: Obtaining, Properties, and Applications), Moscow: Nauka, 2002.

  2. Zaharoff, D.A., Rogers, C.J., Hance, K.W., Schlom, J., and Greiner, J.W., Vaccine, 2007, vol. 25, no. 11, pp. 2085–2094.

    Article  PubMed  CAS  Google Scholar 

  3. Okawa, Y. and Kobayashi, M., Biol. Pharm. Bull., 2003, vol. 26, no. 6, pp. 902–904.

    Article  PubMed  CAS  Google Scholar 

  4. Sherliess, R., Buske, S., Young, K., Weber, B., Rades, T., and Hook, S., Vaccine, 2013, vol. 31, no. 42, pp. 4812–4819.

    Article  CAS  Google Scholar 

  5. Kryzhanovskaya, E.V., Albulov, A.I., Samuilenko, A.Ya., Shinkarev, S.M., Lyul’kova, L.S., Frolova, M.A., Bondareva, N.A., Grin’, S.A., Grin’, A.V., and Khabarov, V.B., Vet. Korml., 2008, no. 4, pp. 34–35.

    Google Scholar 

  6. RF Patent no. 2644339, Byul. Izobret., 2018, no. 4.

Download references

Author information

Authors and Affiliations

  1. All-Russia Research and Technology Institute for Biological Industry, Shchelkovo, Shchelkovo raion, Moscow oblast, 141142, Russia

    M. A. Frolova, A. V. Grin, E. I. Kovaleva & N. V. Melnik

  2. Vitebsk State Academy of Veterinary Medicine, Vitebsk, 210026, Republic of Belarus

    P. A. Krasochko

  3. Bioprogress, LLC, Shchelkovo, Shchelkovo raion, Moscow oblast, 141142, Russia

    A. I. Albulov

Authors
  1. A. I. Albulov
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. M. A. Frolova
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. A. V. Grin
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. E. I. Kovaleva
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. N. V. Melnik
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. P. A. Krasochko
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to A. I. Albulov.

Additional information

Original Russian Text © A.I. Albulov, M.A. Frolova, A.V. Grin, E.I. Kovaleva, N.V. Melnik, P.A. Krasochko, 2018, published in Prikladnaya Biokhimiya i Mikrobiologiya, 2018, Vol. 54, No. 5, pp. 520–524.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Albulov, A.I., Frolova, M.A., Grin, A.V. et al. Application of Chitosan in Veterinary Vaccine Production. Appl Biochem Microbiol 54, 518–521 (2018). https://doi.org/10.1134/S0003683818050034

Download citation

  • Received:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1134/S0003683818050034

Keywords

Search

Navigation