Advances in Gerontology

, Volume 9, Issue 3, pp 327–335 | Cite as

Dose-Dependent Mechanisms of Melatonin on the Functioning of the Cardiovascular System and on the Behavior of Normotensive Rats of Different Ages

  • M. G. Pliss
  • N. V. KuzmenkoEmail author
  • N. S. Rubanova
  • V. A. Tsyrlin


The purpose of the work on normotensive rats of different age groups (3, 15, and 22 months) is to study the synchronism between the functioning of the cardiovascular system and the locomotor activity of animals in open field tests by a single injection of exogenous melatonin in different doses (1 and 10 mg/kg). The studies show a unidirectional dose-dependent effect of exogenous melatonin on the locomotor activity of rats of different ages and an age-dependent effect of melatonin on the parameters of the cardiovascular system. The results show the possible desynchronization between the circadian rhythms of locomotor activity and the functioning of the cardiovascular system with aging, which can lead to a discrepancy between hemodynamic parameters and the level of locomotor activity.


melatonin circadian rhythm cardiovascular system heart rate variability open field test 



Conflict of interest. The authors delate that they have no conflict of interest.

Statement on the welfare of animals. The conditions of the research were in accordance with the ethical standards of the Almazov National Medical Research Centre (St. Petersburg), European Communities Council Directive 1986 (86/609/ EEC), and the rules stated in the Guide for the Care and Use of Laboratory Animals.

This study does not contain any studies involving human participants performed by any of the authors.


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Copyright information

© Pleiades Publishing, Ltd. 2019

Authors and Affiliations

  • M. G. Pliss
    • 1
    • 2
  • N. V. Kuzmenko
    • 1
    • 2
    Email author
  • N. S. Rubanova
    • 2
  • V. A. Tsyrlin
    • 1
  1. 1.Almazov National Medical Research CentreSt. PetersburgRussia
  2. 2.Pavlov First State Medical UniversitySt. PetersburgRussia

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