Advertisement

Polymer Science, Series D

, Volume 12, Issue 1, pp 96–99 | Cite as

Gel-Forming Compounds on the Basis of Derivatives of (Co)Polymers of N-Vinyl Succinimide and Poly(Vinyl Alcohol) as Biofunctional Sorbents

  • L. I. Shal’nova
  • N. A. LavrovEmail author
Article
  • 5 Downloads

Abstract

A polymeric compound of poly(N-vinyl succinamic acid) and poly(vinyl alcohol) is obtained by conducting the polymerization of N-vinyl succinimide and reactions in the chains of its polymer in the presence of poly(vinyl alcohol). The possibility for the intermolecular acetalization and structuring of the (co)polymers of vinyl alcohol containing ionic units of N-vinyl succinamic acid with the use of glutaric aldehyde is determined. The swelling and moisture absorption of the structured (co)polymers and their ability to sorb low-molecular-weight biologically active substances with their prolonged release is studied.

Keywords

polymerization N-vinyl succinimide reactions in polymer chains polymeric compound poly(N-vinyl succinamic acid) poly(vinyl alcohol) structured (co)polymers 

Notes

ACKNOWLEDGMENTS

This work was performed within the framework of a state order from the Ministry of Education and Science of the Russian Federation, 11.5362.2017/8.9.

REFERENCES

  1. 1.
    L. I. Shal’nova, N. A. Lavrov, and A. F. Nikolaev, “The possibility of predicting prolongation of the pharmacological action of biologically active polymeri substances,” Int. Polym. Sci. Technol. 39 (11), 21–27 (2012).Google Scholar
  2. 2.
    M. V. Semenova, S. V. Osadchenko, Ya. O. Mezhuev, M. I. Shtil’man, and I. N. Semenova, “Synthesis of hemocompatible materials based on branched polyvinyl alcohol,” Russ. J. Appl. Chem. 89 (8), 1286–1291 (2016).Google Scholar
  3. 3.
    A. A. Artyukhov, A. A. Morgacheva, A. N. Kuskov, and M. I. Shtil’man, “Biodegradable macroporous polymeric hydrogels based on polyvinyl alcohol and 2‑hydroxyethyl starch,” Vse Mater., Entsikl. Sprav., No. 4, 2–8 (2016).Google Scholar
  4. 4.
    A. A. Artyukhov, A. S. Golunova, L. I. Pashkova, et al., “Macroporous polymeric hydrogels of polyvinyl alcohol containing amino groups,” Plast. Massy, No. 4, 15–21 (2010).Google Scholar
  5. 5.
    O. A. Legon’kova, V. G. Vasil’ev, and L. Yu. Asanova, “Methods for assessing the performance properties of polymeric dressing tools,” Vse Mater., Entsikl. Sprav., No. 8, 10–14 (2015).Google Scholar
  6. 6.
    A. Ya. Sorokin, V. A. Kuznetsova, M. I. Kuzin, et al., RF Inventor’s Certificate No. 1705304, Byull. Izobret., No. 2 (1992).Google Scholar
  7. 7.
    N. A. Lavrov and L. I. Shal’nova, “Specific features of preparation of polymer carriers of physiologically active substances based on N-vinylsuccinimide derivatives,” Polym. Sci., Ser. D 5 (3), 202–204 (2012).Google Scholar
  8. 8.
    N. A. Lavrov, “Theoretical and practical aspects of the synthesis of medical polymers based on N-vinylsuccinimide in aqueous media,” Int. Polym. Sci. Technol. 39 (1), 47–60 (2012).Google Scholar
  9. 9.
    M. D. Mashkovskii, Pharmaceuticals, 16th ed. (Novaya volna, Izd. Umerenkov, Moscow, 2017) [in Russian].Google Scholar

Copyright information

© Pleiades Publishing, Ltd. 2019

Authors and Affiliations

  1. 1.St. Petersburg State Technological Institute (Technical University)St. PetersburgRussia

Personalised recommendations