Advertisement

The Protective Action of Carnosine and Organic Lithium Salts against Ethanol-Induced Oxidative Damage of Blood Plasma Proteins and Lipids of Healthy Persons and Alcoholic Patients

  • V. D. ProkopievaEmail author
  • E. V. Plotnikov
  • E. G. Yarygina
  • N. A. Bokhan
Article
  • 1 Downloads

Abstract

Organic lithium salts containing anionic components (succinate, fumarate, pyruvate) and antiox-idant ascorbate were tested for protection of blood plasma proteins and lipids against ethanol-induced oxidation in vitro. The normothymic agent lithium carbonate and well-known antioxidant dipeptide carnosine (β-alanyl-L-histidine) were used as the reference drugs. The oxidized proteins and lipids were determined by the level of carbonylated proteins (CP) and TBA-reactive substances (TBARS), respectively. In alcoholic patients the level of oxidized proteins and lipids was higher than in healthy persons. Incubation of blood with ethanol resulted in an increase in oxidized proteins and lipids in plasma of healthy persons but had no impact on the level of CP and TBARS in plasma of alcoholic patients. Lithium carbonate, lithium ascorbate, and lithium succinate exhibited protective action against ethanol-induced oxidation of biomolecules of blood plasma of healthy people. These effects were comparable with the carnosine action. The studied compounds had no effect on the level of CP and TBARS in plasma of alcoholic patients.

Keywords:

organic lithium salts ethanol-induced oxidation biomolecules of plasma antioxidants alcoholism- 

Notes

REFERENCES

  1. 1.
    Mashkovskii, M.D., Lekarstvennye Sredstva (Drug Reference Book), Moscow: Novaya Volna, 2006.Google Scholar
  2. 2.
    Plotnikov, E., Voronova, O., Linert, W., Martemianov, D., Korotkova, E., Dorozhko, E., Astashkina, A., Martemianova, I., Ivanova, S., and Bokhan, N., J. App. Pharm. Sci., 2016, vol. 6, no. 1, pp. 86–89.CrossRefGoogle Scholar
  3. 3.
    Balashov, P.P., Anikina, E.Yu., Plotnikov, E.V., Potapov, A.V., and Chuchalin, V.S., Sibirskii Vestnik Psikhiatrii i Narkologii, 2008, no. 4, pp. 83–84.Google Scholar
  4. 4.
    Plotnikov, E.V. and Korotkova, E.I., Rus. Patent no. 2444358, Byul. Izobret., 2012, no. 7.Google Scholar
  5. 5.
    Balashov, P.P., Plotnikov, E.V., and Rastashankii, V.V., Rus. Patent no. 2351326, Byul. Izobret., 2009, no. 10.Google Scholar
  6. 6.
    Skorokhod, N.S., Abramova, N.O., Zlishcheva, E.I., Androsova, T.V., Poleshchuk, L.A., Shurygin, A.Ya., Kravtsov, A.A., and Nemchinova, E.A., Rus. Patent no. 2477722, Byul. Izobret., 2013, no. 8.Google Scholar
  7. 7.
    Zamoshchina, T.A., Bulleten’ Sibirskoi Meditsiny, 2006, vol. 5, S2, pp. 26–29.Google Scholar
  8. 8.
    Boldyrev, A.A., Aldini, G., and Derave, W., Physiological Rev., 2013, vol. 93, no. 4, pp. 1803–1845.  https://doi.org/10.1152/physrev.00039.2012
  9. 9.
    Yarygina, E.G. and Prokopieva, V.D., Sibirskii Vestnik Psikhiatrii i Narkologii, 2015, no. 3, pp. 5–8.Google Scholar
  10. 10.
    Prokopieva, V.D., Bokhan, N.A., Mol’kina, L.G., Patysheva, E.V., Yarygina, E.G., Kozlova, I.L., and Lyashenko, G.P., Vopr. Narkologii, 2007, vol. 5, pp. 17–22.Google Scholar
  11. 11.
    Prokopieva, V.D., Bokhan, N.A., Mol’kina, L.G., Yarygina, E.G., Patysheva, E.V., and Lyashenko, G.P., Sibirskii Vestnik Psikhiatrii i Narkologii, 2008, no. 1, pp. 69–70.Google Scholar
  12. 12.
    Plotnikov, E., Korotkova, E., Voronova, O., Dorozhko, E., Bohan, N., and Plotnikov, S., Physiol. Pharmacol., 2015, vol. 19, pp. 107–113.Google Scholar
  13. 13.
    Levine, R.L., Free Radic. Biol. Med., 2002, vol. 32, pp. 790–796.CrossRefGoogle Scholar
  14. 14.
    Parthasarathy, R., Kattimani, S., and Sridhar, M.G., Ind. J. Psychol. Med., 2015, vol. 37, no. 2, pp. 175–180.  https://doi.org/10.4103/0253-7176.155617 CrossRefGoogle Scholar
  15. 15.
    Galicia-Moreno, M., Rosique-Oramas, D., Medina-Avila, Z., Álvarez-Torres, T., Falcón, D., Higuera-de la Tijera, F., Béjar, Y.L., Cordero-Pérez, P., Muñoz-Espinosa, L., Pérez-Hernández, J.L., Kershenobich, D., and Gutierrez-Reyes, G., Oxid. Med. Cell Longev., 2016, 9370565.  https://doi.org/10.1155/2016/9370565
  16. 16.
    Reddy, V.P., Garrett, M.R., Perry, G., and Smith, M.A., Sci. Aging Knowledge Environ., 2005, vol. 18, 12.Google Scholar

Copyright information

© Pleiades Publishing, Ltd. 2019

Authors and Affiliations

  • V. D. Prokopieva
    • 1
    Email author
  • E. V. Plotnikov
    • 1
    • 2
  • E. G. Yarygina
    • 1
  • N. A. Bokhan
    • 1
  1. 1.Mental Health Research Institute, Tomsk National Research Medical Center (TNRMC), Russian Academy of SciencesTomskRussia
  2. 2.National Research Tomsk Polytechnic UniversityTomskRussia

Personalised recommendations