Cell and Tissue Biology

, Volume 12, Issue 6, pp 460–467 | Cite as

The Cytotoxic Effect of Activated Recombinant Anti-Mullerian Hormone As a Basis for the Development of a New Drug

  • A. Ya. RakEmail author
  • A. V. Trofimov
  • N. V. Pigareva
  • A. S. Simbirtsev
  • A. M. Ischenko


In the present study, the antitumor activity of activated recombinant human anti-Mullerian hormone (rAMH) against the NBL-7 and OVCAR3 cell lines was investigated. It was shown that the hormone contained in highly purified preparations not only has the ability to bind to the recombinant type II receptor (MISRII), but also possesses a cytotoxic effect against cells expressing MISRII. The obtained data may underlie the basis for the development of the first domestic anticancer drug based on activated rAMH.


anti-Mullerian hormone AMH antitumor activity recombinant protein cytotoxicity 



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Copyright information

© Pleiades Publishing, Ltd. 2018

Authors and Affiliations

  • A. Ya. Rak
    • 1
    • 2
    Email author
  • A. V. Trofimov
    • 1
  • N. V. Pigareva
    • 1
  • A. S. Simbirtsev
    • 1
  • A. M. Ischenko
    • 1
  1. 1.State Research Institute of Highly Pure BiopreparationsSt. PetersburgRussia
  2. 2.St. Petersburg State UniversitySt. PetersburgRussia

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